Long-Term Aerobic Exercise Protects against Cisplatin-Induced Nephrotoxicity by Modulating the Expression of IL-6 and HO-1

Autor(es):Mostrar menos -

Saito Miyagi, Mariana Yasue ^[1] ; Seelaender, Marilia ^[2] ; Castoldi, Angela ^[1] ; de Almeida, Danilo Candido ^[1] ; Nova Bacurau, Aline Villa ^[3] ; Andrade-Oliveira, Vinicius ^[1] ; Enjiu, Lucas Maceratesi ^[2] ; Pisciottano, Marcus ^[2] ; Hayashida, Caroline Yuri ^[1] ; Hiyane, Meire Ioshie ^[1] ; Brum, Patricia Chakur ^[3] ; Saraiva Camara, Niels Olsen ^[1] ; Amano, Mariane Tami ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Lab Immunobiol Transplants, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Dept Cell Biol, Canc Metab Res Grp, Inst Biomed Sci, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Phys Educ & Sport, Lab Mol & Cellular Exercise Physiol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 9, n. 10 OCT 1 2014.
• Citações Web of Science: 16

Resumo

Nephrotoxicity is substantial side effect for 30% of patients undergoing cancer therapy with cisplatin and may force them to change or even abandon the treatment. Studies regarding aerobic exercise have shown its efficacy for the treatment of many types of diseases and its capacity to reduce tumors. However, little is known about the impact of physical exercise on cisplatin-induced acute kidney injury (AKI). In the present study, our aim was to investigate the role of physical exercise in AKI induced by cisplatin. We submitted C57Bl6 male mice to seven weeks of chronic exercise on a training treadmill and treated them with single i.p. injection of cisplatin (20 mg/kg) in the last week. Exercise efficacy was confirmed by an increased capillary-to-fiber ratio in the gastrocnemius muscle of exercised groups (EX and CIS-EX). The group submitted to exercise before cisplatin administration (CIS-EX) exhibited less weight loss and decreased serum urea levels compared to the cisplatin group (CIS). Exercise also showed a protective role against cisplatin-induced cell death in the kidney. The CIS-EX group showed a lower inflammatory response, with less TNF and IL-10 expression in the kidney and serum. In the same group, we observed an increase of IL-6 and HO-1 expression in the kidney. Taken together, our results indicate that chronic aerobic exercise is able to attenuate AKI by inducing IL-6 and HO-1 production, which results in lower inflammatory and apoptotic profiles in the kidney. (AU)

• Processo FAPESP: 12/50079-0 - Inflamação sistêmica em pacientes com caquexia associada ao câncer: mecanismos e estratégias terapêuticas, uma abordagem em medicina translacional
• Beneficiário: Marilia Cerqueira Leite Seelaender
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 12/10435-1 - A influência da via mtor na modulação de macrófagos e suas consequências na doença renal crônica experimental
• Beneficiário: Mariane Tami Amano
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 12/02270-2 - Novos mecanismos celulares, moleculares e imunológicos das lesões renais agudas e crônicas: busca por novas estratégias terapêuticas
• Beneficiário: Niels Olsen Saraiva Câmara
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 11/10349-5 - O papel do exercício físico na lesão renal induzida pela cisplatina
• Beneficiário: Mariana Yasue Saito Miyagi
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica