Fc gamma RIIa and Fc gamma RIIIb polymorphisms and associations with clinical manifestations in systemic lupus erythematosus patients

Autor(es)

Costa Vigato-Ferreira, Isabel Cristina ^[1] ; Toller-Kawahisa, Juliana Escher ^[2] ; Tres Pancoto, Joao Alexandre ^[3] ; Mendes-Junior, Celso Teixeira ^[4] ; Martinez, Edson Zangiacomi ^[5] ; Donadi, Eduardo Antonio ^[6] ; Louzada-Junior, Paulo ^[6] ; Cavalcanti Del Lama, Jose Eduardo ^[1] ; Marzocchi-Machado, Cleni Mara ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, BR-14040903 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Fac Med Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil

^[3] Univ Fed Espirito Santo, Dept Ciencias Saude, Sao Mateus, ES - Brazil

^[4] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, BR-14040903 Ribeirao Preto, SP - Brazil

^[5] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Social Med, BR-14040903 Ribeirao Preto, SP - Brazil

^[6] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Clin Med, BR-14040903 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: AUTOIMMUNITY; v. 47, n. 7, p. 451-458, NOV 2014.
• Citações Web of Science: 7

Resumo

In this study, we aimed to investigate whether the distribution of the Fc gamma RIIa and Fc gamma RIIIb polymorphisms determines susceptibility to systemic lupus erythematosus (SLE) and acts as predictors of SLE clinical manifestations in the Brazilian patients. A total of 157 patients that fulfilled the American College of Rheumatology classification criteria for SLE and 160 healthy volunteers were included in this study. FCGR2A and FCGR3B genotypes were determined by polymerase chain reaction-based allotyping methods with allele-specific primers; the clinical features were obtained from the patients' official medical records. In the case of Fc gamma RIIa polymorphism, it was observed association of the allele FCGR2A-R-131 (p = 0.02, odds ratio (OR) = 1.44) and genotype RR-131 (p = 0.03, OR = 2.09) with SLE. These associations were higher with allele (p<0.01, OR = 1.67) as well genotype (p = 0.01, OR = 2.85) when lupus nephritis was considered. In contrast, the allele FCGR2A-H-131 was associated with susceptibility to arthritis and anti-DNA antibodies (p = 0.05 for both). As for Fc gamma RIIIb polymorphism, skewing did not differ significantly between patients and controls, however the genotype FCGR3B{*}02{*}02 was associated with susceptibility to arthritis (p = 0.02) and malar rash (p = 0.03), but no association with nephritis was found. The results demonstrate that Fc gamma RIIa polymorphism is associated with susceptibility to SLE in Brazilian patients, whereas for Fc gamma RIIIb polymorphism no association was found. However, notably, both polymorphisms present allelic variants that influence the clinical manifestations and may contribute to the pathogenesis of the disease. In addition, to our knowledge, this is the first study considering the frequency of Fc gamma RIIIb polymorphism in Brazilian SLE patients. (AU)

• Processo FAPESP: 09/12649-6 - Associação dos polimorfismos dos FcgamaR e do CR3 com as infecções bacterianas no lúpus eritematoso sistêmico: determinação das combinações dos genótipos e sua influência no burst oxidativo dos neutrófilos
• Beneficiário: Juliana Escher Toller
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 09/14732-8 - Associação dos polimorfismos dos FcgamaR e do CR3 com as infecções bacterianas no lúpus eritematoso sistêmico: determinação das combinações dos genótipos e sua influência nas funções mediadas por neutrófilos
• Beneficiário: Cleni Mara Marzocchi Machado
• Modalidade de apoio: Auxílio à Pesquisa - Regular