Association of Interleukin 4 Gene Polymorphisms With Dental Implant Loss

Autor(es)

Pigossi, Suzane C. ^[1] ; Alvim-Pereira, Fabiano ^[2] ; Alvim-Pereira, Claudia C. K. ^[3] ; Trevilatto, Paula C. ^[4] ; Scarel-Caminaga, Raquel M. ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, UNESP, Sch Dent Araraquara, Dept Morphol, Araraquara - Brazil

^[2] Univ Fed Sergipe, Dept Dent, Lagarto - Brazil

^[3] Univ Fed Sergipe, Dept Med, Lagarto, Sergipe - Brazil

^[4] Pontificia Univ Catolica Parana, Ctr Hlth & Biol Sci, Curitiba, Parana - Brazil

• Tipo de documento: Artigo Científico
• Fonte: IMPLANT DENTISTRY; v. 23, n. 6, p. 723-731, DEC 2014.
• Citações Web of Science: 9

Resumo

Purpose: The purpose of this study was to investigate the association between interleukin 4 (IL4) polymorphisms/haplotypes and dental implant loss. Materials and Methods: Two hundred and seventy eight (n = 278) unrelated patients were divided into 2 groups: (1) control group (C) composed of 186 individuals presenting at least 1 osseointegrated implant and (2) study group (S) composed of 94 individuals presenting at least 1 implant loss. After DNA collection, IL4 polymorphisms were investigated by polymerase chain reaction (PCR)restriction fragment length polymorphism and for the variable number of tandem repeat (VNTR) only by PCR. Results: No association between alleles/genotypes of -590 (C/T) (P = 0.9704/P = 0.5992) and VNTR (P = 0.7155/P = 0.8789) polymorphisms and implant loss were found between the groups. Regarding +33 (C/T) polymorphism, no difference was found in genotype frequency (P = 0.1288), but the C allele was associated with implant loss (P = 0.0236, odds ratio = 1.61, 95% confidence interval = 1.1-2.4). Haplotype analysis showed no statistical differences between the groups. Conclusion: The C allele of the +33 (C/T) polymorphism in the IL4 gene was associated with susceptibility to dental implant loss in Brazilians in the studied population. (AU)

• Processo FAPESP: 09/09932-8 - Investigação de polimorfismos no gene da interleucina 4 em indivíduos com perda de implantes osseointegráveis
• Beneficiário: Suzane Cristina Pigossi
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica