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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Association of Interleukin 4 Gene Polymorphisms With Dental Implant Loss

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Author(s):
Pigossi, Suzane C. [1] ; Alvim-Pereira, Fabiano [2] ; Alvim-Pereira, Claudia C. K. [3] ; Trevilatto, Paula C. [4] ; Scarel-Caminaga, Raquel M. [1]
Total Authors: 5
Affiliation:
[1] Sao Paulo State Univ, UNESP, Sch Dent Araraquara, Dept Morphol, Araraquara - Brazil
[2] Univ Fed Sergipe, Dept Dent, Lagarto - Brazil
[3] Univ Fed Sergipe, Dept Med, Lagarto, Sergipe - Brazil
[4] Pontificia Univ Catolica Parana, Ctr Hlth & Biol Sci, Curitiba, Parana - Brazil
Total Affiliations: 4
Document type: Journal article
Source: IMPLANT DENTISTRY; v. 23, n. 6, p. 723-731, DEC 2014.
Web of Science Citations: 9
Abstract

Purpose: The purpose of this study was to investigate the association between interleukin 4 (IL4) polymorphisms/haplotypes and dental implant loss. Materials and Methods: Two hundred and seventy eight (n = 278) unrelated patients were divided into 2 groups: (1) control group (C) composed of 186 individuals presenting at least 1 osseointegrated implant and (2) study group (S) composed of 94 individuals presenting at least 1 implant loss. After DNA collection, IL4 polymorphisms were investigated by polymerase chain reaction (PCR)restriction fragment length polymorphism and for the variable number of tandem repeat (VNTR) only by PCR. Results: No association between alleles/genotypes of -590 (C/T) (P = 0.9704/P = 0.5992) and VNTR (P = 0.7155/P = 0.8789) polymorphisms and implant loss were found between the groups. Regarding +33 (C/T) polymorphism, no difference was found in genotype frequency (P = 0.1288), but the C allele was associated with implant loss (P = 0.0236, odds ratio = 1.61, 95% confidence interval = 1.1-2.4). Haplotype analysis showed no statistical differences between the groups. Conclusion: The C allele of the +33 (C/T) polymorphism in the IL4 gene was associated with susceptibility to dental implant loss in Brazilians in the studied population. (AU)

FAPESP's process: 09/09932-8 - Investigation of polymorphisms in the interleukin 4 gene in individuals with dental implant loss
Grantee:Suzane Cristina Pigossi
Support Opportunities: Scholarships in Brazil - Scientific Initiation