Bovine hydroxyapatite (Bio-Oss (R)) induces osteocalcin, RANK-L and osteoprotegerin expression in sinus lift of rabbits

Autor(es)

Chaves, Marcelo Donizeti ^[1] ; de Souza Nunes, Leandro Soeiro ^[2] ; de Oliveira, Renato Victor ^[2] ; Holgado, Leandro Andrade ^[2] ; Nary Filho, Hugo ; Matsumoto, Mariza Akemi ^[2] ; Ribeiro, Daniel Araki ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, UNIFESP, Dept Biociencias, BR-10060001 Santos, SP - Brazil

^[2] Univ Sagrado Coracao, Sch Dent, Dept Hlth Sci, Discipline Oral & Maxillofacial Surg, Bauru, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY; v. 40, n. 8, p. E315-E320, DEC 2012.
• Citações Web of Science: 11

Resumo

Purpose: The aim of this study was to analyze and compare the expression of osteocalcin, RANK-L, osteoprotegerin, in sinus lift procedures using bovine hydroxyapatite (HA). Material and methods: Twenty four male rabbits underwent bilateral sinus lift procedures were distributed into two groups, according to the sinus filling material: Group 1) autogenous bone graft; and Group 2) bovine HA. All groups were sacrificed after 14 and 30 days, for microscopic and immunohistochemistry analysis. Results: At 14 days after surgery, discrete osteogenesis was observed in the highly vascularized granulation tissue surrounding HA particles, as well as woven bone deposition on the biomaterial surface. Following 30 days, well organized bone trabeculas were seen surrounding the HA granules presenting areas of osteogenic activity. Morphometric findings did not show remarkable differences between groups. Bovine HA induced similar osteocalcin, RANK-L, osteoprotegerin immunoexpressivity when compared to autogenous bone graft group for both periods evaluated in this setting. Conclusion: Taken together, these data are consistent with the notion that HA has a similar biological behavior to autogenous bone graft in sinus lift of rabbits. (C) 2012 European Association for Cranio-Maxillo-Facial Surgery. (AU)

• Processo FAPESP: 07/04767-3 - Biocompatibilidade de polietileno poroso de alta densidade, hidroxiapatita bovina inorgânica e b-tricalcio fosfato em coelhos: parâmetros morfológicos macro e microscópicos e imunoistoquímicos
• Beneficiário: Mariza Akemi Matsumoto
• Modalidade de apoio: Auxílio à Pesquisa - Regular