Sleep deprivation alters energy homeostasis through non-compensatory alterations in hypothalamic insulin receptors in Wistar rats

Autor(es)

Moraes, Danilo Alves ^[1] ; Venancio, Daniel Paulino ^[1] ; Suchecki, Deborah ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Psicobiol, BR-04023062 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Hormones and Behavior; v. 66, n. 5, p. 705-712, NOV 2014.
• Citações Web of Science: 9

Resumo

Studies have shown a gradual reduction of sleep time in the general population, accompanied by increased food intake, representing a risk for developing obesity, type II diabetes and cardiovascular disease. Rats subjected to paradoxical sleep deprivation (PSD) exhibit feeding and metabolic alterations, both of which are regulated by the communication between peripheral signals and the hypothalamus. This study aimed to investigate the daily change of 96 h of PSD-induced food intake, body weight, blood glucose, plasma insulin and leptin concentrations and the expression of their receptors in the hypothalamus of Wistar rats. Food intake was assessed during the light and dark phases and was progressively increased in sleep-deprived animals, during the light phase. PSD produced body weight loss, particularly on the first day, and decreased plasma insulin and leptin levels, without change in blood glucose levels. Reduced leptin levels were compensated by increased expression of leptin receptors in the hypothalamus, whereas no compensations occurred in insulin receptors. The present results on body weight loss and increased food intake replicate previous studies from our group. The fact that reduced insulin levels did not lead to compensatory changes in hypothalamic insulin receptors, suggests that this hormone may be, at least in part, responsible for PSD-induced dysregulation in energy metabolism. (C) 2014 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 12/23488-6 - Mecanismos hipotalâmicos e periféricos envolvidos nas alterações metabólicas decorrentes da privação ou da restrição de sono REM
• Beneficiário: Deborah Suchecki
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/50691-4 - Efeito da restrição de sono sobre o desenvolvimento de síndrome metabólica em ratos
• Beneficiário: Daniel Paulino Venancio
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 10/14311-0 - Investigação das alterações hipotalâmicas e periféricas relacionadas ao metabolismo causadas pelo exercício intenso e exaustivo em camundongos
• Beneficiário: Danilo Alves de Moraes
• Modalidade de apoio: Bolsas no Brasil - Mestrado