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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Sleep deprivation alters energy homeostasis through non-compensatory alterations in hypothalamic insulin receptors in Wistar rats

Full text
Author(s):
Moraes, Danilo Alves [1] ; Venancio, Daniel Paulino [1] ; Suchecki, Deborah [1]
Total Authors: 3
Affiliation:
[1] Univ Fed Sao Paulo, Dept Psicobiol, BR-04023062 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Hormones and Behavior; v. 66, n. 5, p. 705-712, NOV 2014.
Web of Science Citations: 9
Abstract

Studies have shown a gradual reduction of sleep time in the general population, accompanied by increased food intake, representing a risk for developing obesity, type II diabetes and cardiovascular disease. Rats subjected to paradoxical sleep deprivation (PSD) exhibit feeding and metabolic alterations, both of which are regulated by the communication between peripheral signals and the hypothalamus. This study aimed to investigate the daily change of 96 h of PSD-induced food intake, body weight, blood glucose, plasma insulin and leptin concentrations and the expression of their receptors in the hypothalamus of Wistar rats. Food intake was assessed during the light and dark phases and was progressively increased in sleep-deprived animals, during the light phase. PSD produced body weight loss, particularly on the first day, and decreased plasma insulin and leptin levels, without change in blood glucose levels. Reduced leptin levels were compensated by increased expression of leptin receptors in the hypothalamus, whereas no compensations occurred in insulin receptors. The present results on body weight loss and increased food intake replicate previous studies from our group. The fact that reduced insulin levels did not lead to compensatory changes in hypothalamic insulin receptors, suggests that this hormone may be, at least in part, responsible for PSD-induced dysregulation in energy metabolism. (C) 2014 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 12/23488-6 - Hypothalamic and peripheral mechanisms involved in metabolic alterations induced by REM sleep deprivation or REM sleep restriction
Grantee:Deborah Suchecki
Support Opportunities: Regular Research Grants
FAPESP's process: 10/14311-0 - Metabolism-related hypothalamic and peripheral alterations induced by intense and exhaustive exercise in mice
Grantee:Danilo Alves de Moraes
Support Opportunities: Scholarships in Brazil - Master