Personalized Preventive Medicine: Genetics and the Response to Regular Exercise in Preventive Interventionse

Autor(es):Mostrar menos -

Bouchard, Claude ^[1] ; Antunes-Correa, Ligia M. ^[2] ; Ashley, Euan A. ^{[3, 4]} ; Franklin, Nina ^[5] ; Hwang, Paul M. ^[6] ; Mattsson, C. Mikael ^{[3, 7]} ; Negrao, Carlos E. ^{[2, 8]} ; Phillips, Shane A. ^[5] ; Sarzynski, Mark A. ^[1] ; Wang, Ping-yuan ^[6] ; Wheeler, Matthew T. ^{[3, 4]}

Afiliação do(s) autor(es)

^[1] Pennington Biomed Res Ctr, Human Genom Lab, Baton Rouge, LA 70806 - USA

^[2] Univ Sao Paulo, Sch Med, Heart Inst InCor, Sao Paulo - Brazil

^[3] Stanford Univ, Div Cardiovasc Med, Ctr Inherited Cardiovasc Dis, Stanford, CA 94305 - USA

^[4] Stanford Univ, Sch Med, Cardiovasc Inst, Stanford, CA 94305 - USA

^[5] Univ Illinois, Dept Med, Integrat Physiol Lab, Dept Phys Therapy, Chicago, IL - USA

^[6] NHLBI, NIH, Bethesda, MD 20892 - USA

^[7] Swedish Sch Sport & Hlth Sci, Stockholm - Sweden

^[8] Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: PROGRESS IN CARDIOVASCULAR DISEASES; v. 57, n. 4, p. 337-346, JAN-FEB 2015.
• Citações Web of Science: 24

Resumo

Regular exercise and a physically active lifestyle have favorable effects on health. Several issues related to this theme are addressed in this report. A comment on the requirements of personalized exercise medicine and in-depth biological profiling along with the opportunities that they offer is presented. This is followed by a brief overview of the evidence for the contributions of genetic differences to the ability to benefit from regular exercise. Subsequently, studies showing that mutations in TP53 influence exercise capacity in mice and humans are succinctly described. The evidence for effects of exercise on endothelial function in health and disease also is covered. Finally, changes in cardiac and skeletal muscle in response to exercise and their implications for patients with cardiac disease are summarized. Innovative research strategies are needed to define the molecular mechanisms involved in adaptation to exercise and to translate them into useful clinical and public health applications. (C) 2014 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 10/50048-1 - Bases celulares e funcionais do exercício físico na doença cardiovascular
• Beneficiário: Carlos Eduardo Negrão
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/15651-7 - Efeitos do Treinamento Físico Aeróbio Associado ao Treinamento Muscular Inspiratório na Miopatia Esquelética em Pacientes com Insuficiência Cardíaca
• Beneficiário: Lígia de Moraes Antunes Corrêa
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/07607-8 - CMPO - Centro Multidisciplinar de Pesquisa em Obesidade e Doenças Associadas
• Beneficiário: Licio Augusto Velloso
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs