Personalized Preventive Medicine: Genetics and the Response to Regular Exercise in Preventive Interventionse

Author(s):Show less -

Bouchard, Claude ^[1] ; Antunes-Correa, Ligia M. ^[2] ; Ashley, Euan A. ^{[3, 4]} ; Franklin, Nina ^[5] ; Hwang, Paul M. ^[6] ; Mattsson, C. Mikael ^{[3, 7]} ; Negrao, Carlos E. ^{[2, 8]} ; Phillips, Shane A. ^[5] ; Sarzynski, Mark A. ^[1] ; Wang, Ping-yuan ^[6] ; Wheeler, Matthew T. ^{[3, 4]}

Affiliation

^[1] Pennington Biomed Res Ctr, Human Genom Lab, Baton Rouge, LA 70806 - USA

^[2] Univ Sao Paulo, Sch Med, Heart Inst InCor, Sao Paulo - Brazil

^[3] Stanford Univ, Div Cardiovasc Med, Ctr Inherited Cardiovasc Dis, Stanford, CA 94305 - USA

^[4] Stanford Univ, Sch Med, Cardiovasc Inst, Stanford, CA 94305 - USA

^[5] Univ Illinois, Dept Med, Integrat Physiol Lab, Dept Phys Therapy, Chicago, IL - USA

^[6] NHLBI, NIH, Bethesda, MD 20892 - USA

^[7] Swedish Sch Sport & Hlth Sci, Stockholm - Sweden

^[8] Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo - Brazil

• Document type: Review article
• Source: PROGRESS IN CARDIOVASCULAR DISEASES; v. 57, n. 4, p. 337-346, JAN-FEB 2015.
• Web of Science Citations: 24

Abstract

Regular exercise and a physically active lifestyle have favorable effects on health. Several issues related to this theme are addressed in this report. A comment on the requirements of personalized exercise medicine and in-depth biological profiling along with the opportunities that they offer is presented. This is followed by a brief overview of the evidence for the contributions of genetic differences to the ability to benefit from regular exercise. Subsequently, studies showing that mutations in TP53 influence exercise capacity in mice and humans are succinctly described. The evidence for effects of exercise on endothelial function in health and disease also is covered. Finally, changes in cardiac and skeletal muscle in response to exercise and their implications for patients with cardiac disease are summarized. Innovative research strategies are needed to define the molecular mechanisms involved in adaptation to exercise and to translate them into useful clinical and public health applications. (C) 2014 Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 10/50048-1 - Cellular and functional bases of exercise in cardiovascular diseases
• Grantee: Carlos Eduardo Negrão
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 13/15651-7 - Effects of Aerobic Exercise Training Associated with Inspiratory Muscle Training on Skeletal Myopathy in Patients with Heart Failure
• Grantee: Lígia de Moraes Antunes Corrêa
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center
• Grantee: Licio Augusto Velloso
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC