Cellular and functional bases of exercise in cardiovascular diseases

• Grant number: 10/50048-1
• Support type: Research Projects - Thematic Grants
• Duration: August 01, 2010 - January 31, 2016
• Field of knowledge: Health Sciences - Medicine
• Principal researcher: Carlos Eduardo Negrão
• Grantee: Carlos Eduardo Negrão
• Home Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Pesquisadores principais: Antonio Carlos Pereira-Barretto ; Edilamar Menezes de Oliveira ; Luciana Venturini Rossoni ; Maria Urbana Pinto Brandão Rondon ; Patricia Chakur Brum
• Associated grant(s): 14/22335-7 - Study of perivascular innervation in arteries from post-myocardial infarction rats: effect of physical training, AV.EXT
• Associated scholarship(s): 14/13690-8 - Role of exercise training on prevention of cardiotoxicity provoked by doxorubicin, BP.PD; 13/10472-7 - Swimming exercise training in vascular remodeling of coronary arteries of spontaneously hypertensive rats: effects on the expression of microRNAs and perspective of identifying therapeutic targets., BP.PD

Abstract

Accumulated evidences show that exercise training plays an important role in cardiovascular disease. The present study will focus on the effects that exercise training may have on muscle mechanoreflex and metaboreflex controls of sympathetic nerve activity in patients with heart failure. In addition, we will investigate the cellular mechanisms involved in these controls. At a vascular level, we will study the effects of exercise training on miRNA expression involved in the cardiac angiogenesis in spontaneously hypertensive rats. Also, we will investigate the influence of exercise training on pro-inflammation, oxidative stress and antioxidant enzymes in endothelial cells of the human femoral artery, and on the vascular morphology and function of animals with heart failure. The final section will be dedicated to the investigation of the effects of exercise training on cardiac remodeling and skeletal myopathy in heart failure. To accomplish this goal, we will study the effects of exercise training on cardiac calcineurine pathway and skeletal muscle protein synthesis and degradation with two different approaches: heart failure patients submitted to cardiac resynchronization therapy and heart failure patients undergoing testosterone therapy. Furthermore, we will study the role of angiotensin II on the amelioration of muscle myopathy provoked by exercise training. Finally, we close this section investigating if the improvement of cardiac and skeletal myopathy in heart failure is associated with exercise training intensity. (AU)

Scientific publications

(47)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DARDI, PATRIZIA; PERAZZA, LAIS ROSSI; COUTO, GISELE KRUGER; CAMPOS, GIANNE PAUL; AGGUM CAPETTINI, LUCIANO DOS SANTOS; ROSSONI, LUCIANA VENTURINI. ena cava presents endothelial dysfunction prior to thoracic aorta in heart failure: the pivotal role of nNOS uncoupling/oxidative stres. Clinical Science, v. 135, n. 23, p. 2625-2641, DEC 2021. Web of Science Citations: 0.

BERNAK-OLIVEIRA, ANGELO; GUIZONI, DANIELE M.; CHIAVEGATTO, SILVANA; DAVEL, ANA P.; V. ROSSONI, LUCIANA. The protective role of neuronal nitric oxide synthase in endothelial vasodilation in chronic beta-adrenoceptor overstimulation. Life Sciences, v. 285, NOV 15 2021. Web of Science Citations: 0.

TOSCHI-DIAS, EDGAR; MONTANO, NICOLA; TOBALDINI, ELEONORA; TREVIZAN, PATRICIA F.; GROEHS, V, RAPHAELA; ANTUNES-CORREA, LIGIA M.; NOBRE, THAIS S.; LOBO, DENISE M.; SALES, ALLAN R. K.; UENO-PARDI, LINDA M.; DE MATOS, LUCIANA D. N. J.; OLIVEIRA, PATRICIA A.; BRAGA, ANA MARIA F. W.; ALVES, MARIA JANIEIRE N. N.; NEGRAO, CARLOS E.; RONDON, MARIA URBANA P. B. Oscillatory Pattern of Sympathetic Nerve Bursts Is Associated With Baroreflex Function in Heart Failure Patients With Reduced Ejection Fraction. FRONTIERS IN NEUROSCIENCE, v. 15, AUG 31 2021. Web of Science Citations: 0.

BLANCO-RIVERO, JAVIER; COUTO, GISELE K.; PAULA, SULIANA M.; FONTES, MILENE T.; ROSSONI, V, LUCIANA. Enhanced sympathetic neurotransduction in the superior mesenteric artery in a rat model of heart failure: role of noradrenaline and ATP. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 320, n. 2, p. H563-H574, FEB 2021. Web of Science Citations: 0.

SARMENTO, ADRIANA OLIVEIRA; ANTUNES-CORREA, LIGIA M.; ALVES, MARIA J. N. N.; BACURAU, ALINE V. N.; FONSECA, KEILA C. B.; PESSOA, FERNANDA G.; LOBO, DENISE M. L.; MOREIRA, LEILA D. P.; TROMBETTA, IVANI C.; RONDON, MARIA U. P. B.; RONDON, EDUARDO; VIEIRA, MARCELO L. C.; RAMIRES, FELIX J. A.; DO BRASILEIRO-SANTOS, MARIA SOCORRO; BRUM, PATRICIA C.; MADY, CHARLES; NEGRAO, CARLOS E.; THOMAS, SCOTT; IANNI, BARBARA M. Effect of exercise training on cardiovascular autonomic and muscular function in subclinical Chagas cardiomyopathy: a randomized controlled trial. CLINICAL AUTONOMIC RESEARCH, v. 31, n. 2 SEP 2020. Web of Science Citations: 0.

PAULA, SULIANA M.; COUTO, GISELE K.; FONTES, MILENE T.; COSTA, SORAIA K.; NEGRAO, CARLOS E.; MILL, JOSE G.; ROSSONI, V, LUCIANA. Exercise training restores the myogenic response in skeletal muscle resistance arteries and corrects peripheral edema in rats with heart failure. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 317, n. 1, p. H87-H96, JUL 2019. Web of Science Citations: 0.

TOSCHI-DIAS, EDGAR; TROMBETTA, IVANI C.; SILVA, VALDO J. D.; MAKI-NUNES, CRISTIANE; CEPEDA, FELIPE X.; ALVES, MARIA JANIEIRE N. N.; CARVALHO, GLAUCE L.; DRAGER, LUCIANO F.; LORENZI-FILHO, GERALDO; NEGRAO, CARLOS E.; RONDON, MARIA URBANA P. B. Diet associated with exercise improves baroreflex control of sympathetic nerve activity in metabolic syndrome and sleep apnea patients. Sleep and Breathing, v. 23, n. 1, p. 143-151, MAR 2019. Web of Science Citations: 2.

GRAZIELA AMARO-VICENTE; MATEUS C. LATERZA; DANIEL G. MARTINEZ; MARIA JANIEIRE N. N. ALVES; IVANI C. TROMBETTA; ANA MARIA F. W. BRAGA; EDGAR TOSCHI-DIAS; MARIA URBANA P. B. RONDON. Exercise Training Improves Heart Rate Recovery after Exercise in Hypertension. Motriz: rev. educ. fis., v. 25, n. 1 2019-08-22.

FERNANDES, TIAGO; BARRETTI, DIEGO LOPES; PHILLIPS, M. IAN; OLIVEIRA, EDILAMAR MENEZES. Exercise training prevents obesity-associated disorders: Role of miRNA-208a and MED13. Molecular and Cellular Endocrinology, v. 476, p. 148-154, NOV 15 2018. Web of Science Citations: 1.

ALVES, CLEBER RENE; FERNANDES, TIAGO; LEMOS, JR., JOSE RIBEIRO; MAGALHAES, FLAVIO DE CASTRO; TROMBETTA, IVANI CREDIDIO; ALVES, GUILHERME BARRETO; ALVES DA MOTA, GLORIA DE FATIMA; DIAS, RODRIGO GONCALVES; PEREIRA, ALEXANDRE COSTA; KRIEGER, JOSE EDUARDO; NEGRAO, CARLOS EDUARDO; OLIVEIRA, EDILAMAR MENEZES. Aerobic exercise training differentially affects ACE C- and N-domain activities in humans: Interactions with ACE I/D polymorphism and association with vascular reactivity. JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, v. 19, n. 2 APR 9 2018. Web of Science Citations: 1.

COUTO, GISELE K.; PAULA, SULIANA M.; GOMES-SANTOS, IGOR L.; NEGRAO, CARLOS EDUARDO; ROSSONI, V, LUCIANA. Exercise training induces eNOS coupling and restores relaxation in coronary arteries of heart failure rats. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 314, n. 4, p. H878-H887, APR 2018. Web of Science Citations: 6.

FERNANDES, TIAGO; CASAES, LILIAN; SOCI, URSULA; SILVEIRA, ANDRE; GOMES, JOAO; BARRETTI, DIEGO; ROQUE, FERNANDA; OLIVEIRA, EDILAMAR. Exercise Training Restores the Cardiac Microrna-16 Levels Preventing Microvascular Rarefaction in Obese Zucker Rats. Obesity Facts, v. 11, n. 1, p. 15-24, 2018. Web of Science Citations: 4.

JORDAO, CAMILA P.; FERNANDES, TIAGO; TANAKA, LEONARDO YUJI; GRASSMANN BECHARA, LUIZ R.; OLIVEIRA DE SOUSA, LUIS GUSTAVO; OLIVEIRA, EDILAMAR M.; RAMIRES, PAULO RIZZO. Aerobic Swim Training Restores Aortic Endothelial Function by Decreasing Superoxide Levels in Spontaneously Hypertensive Rats. Clinics, v. 72, n. 5, p. 310-316, MAY 2017. Web of Science Citations: 0.

ANTUNES-CORREA, LIGIA M.; UENO-PARDI, LINDA M.; TREVIZAN, PATRICIA F.; SANTOS, MARCELO R.; DA SILVA, CARLOS HENRIQUE P.; FRANCO, FABIO G. M.; ALVES, MARIA JANIEIRE N. N.; RONDON, MARIA URBANA P. B.; NEGRAO, CARLOS E. The influence of aetiology on the benefits of exercise training in patients with heart failure. EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, v. 24, n. 4, p. 365-372, MAR 2017. Web of Science Citations: 9.

FERREIRA-SANTOS, LARISSA; MARTINEZ, DANIEL G.; NICOLAU, JOSE CARLOS; MOREIRA, HUMBERTO G.; ALVES, MARIA JANIEIRE; PEREIRA, ALEXANDRE C.; TROMBETTA, IVANI C.; NEGRAO, CARLOS EDUARDO; RONDON, MARIA URBANA P. B. Neurovascular control during exercise in acute coronary syndrome patients with Gln27Glu polymorphism of beta(2)-adrenergic receptor. PLoS One, v. 12, n. 2 FEB 24 2017. Web of Science Citations: 1.

SILVEIRA, ANDRE C.; FERNANDES, TIAGO; SOCI, URSULA P. R.; GOMES, JOAO L. P.; BARRETTI, DIEGO L.; MOTA, GLORIA G. F.; NEGRAO, CARLOS EDUARDO; OLIVEIRA, EDILAMAR M. Exercise Training Restores Cardiac MicroRNA-1 and MicroRNA-29c to Nonpathological Levels in Obese Rats. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2017. Web of Science Citations: 3.

NOBRE, T. S.; GROEHS, R. V.; AZEVEDO, L. F.; ANTUNES-CORREA, L. M.; MARTINEZ, D. G.; ALVES, M. J. N. N.; NEGRAO, C. E. Post-Exercise Neurovascular Control in Chronic Heart Failure Patients. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, v. 37, n. 13, p. 1073-1079, DEC 2016. Web of Science Citations: 1.

RENO SOCI, URSULA PAULA; FERNANDES, TIAGO; BARAUNA, VALERIO GARRONE; HASHIMOTO, NARA YUMI; ALVES MOTA, GLORIA DE FATIMA; ROSA, KALEIZU TEODORO; IRIGOYEN, MARIA CLAUDIA; PHILIPS, MICHAEL IAN; DE OLIVEIRA, EDILAMAR MENEZES. Epigenetic control of exercise training-induced cardiac hypertrophy by miR-208. Clinical Science, v. 130, n. 22, p. 2005-2015, NOV 1 2016. Web of Science Citations: 11.

BOZI, LUIZ H. M.; JANNIG, PAULO R.; ROLIM, NATALE; VOLTARELLI, VANESSA A.; DOURADO, PAULO M. M.; WISLOFF, ULRIK; BRUM, PATRICIA C. Aerobic exercise training rescues cardiac protein quality control and blunts endoplasmic reticulum stress in heart failure rats. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v. 20, n. 11, p. 2208-2212, NOV 2016. Web of Science Citations: 17.

LOBO, DENISE M. L.; TREVIZAN, PATRICIA F.; TOSCHI-DIAS, EDGAR; OLIVEIRA, PATRICIA A.; PIVETA, RAFAEL B.; ALMEIDA, DIRCEU R.; MADY, CHARLES; BOCCHI, EDIMAR A.; LORENZI-FILHO, GERALDO; MIDDLEKAUFF, HOLLY R.; NEGRAO, CARLOS E. Sleep-Disordered Breathing Exacerbates Muscle Vasoconstriction and Sympathetic Neural Activation in Patients with Systolic Heart Failure. Circulation-Heart Failure, v. 9, n. 11 NOV 2016. Web of Science Citations: 5.

NOBRE, THAIS S.; ANTUNES-CORREA, LIGIA M.; GROEHS, RAPHAELA V.; ALVES, MARIA JANIEIRE N. N.; SARMENTO, ADRIANA O.; BACURAU, ALINE V.; URIAS, URSULA; ALVES, GUILHERME B.; RONDON, MARIA URBANA P. B.; BRUM, PATRICIA C.; MARTINELLI, MARTINO; MIDDLEKAUFF, HOLLY R.; NEGRAO, CARLOS E. Exercise training improves neurovascular control and calcium cycling gene expression in patients with heart failure with cardiac resynchronization therapy. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 311, n. 5, p. H1180-H1188, NOV 2016. Web of Science Citations: 4.

GROEHS, RAPHAELA V.; ANTUNES-CORREA, LIGIA M.; NOBRE, THAIS S.; ALVES, MARIA-JANIEIRE N. N.; RONDON, MARIA URBANA P. B.; PEREIRA BARRETO, ANTONIO CARLOS; NEGRAO, CARLOS E. Muscle electrical stimulation improves neurovascular control and exercise tolerance in hospitalised advanced heart failure patients. EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, v. 23, n. 15, p. 1599-1608, OCT 2016. Web of Science Citations: 7.

BACURAU, ALINE V. N.; JANNIG, PAULO R.; DE MORAES, WILSON M. A. M.; CUNHA, TELMA F.; MEDEIROS, ALESSANDRA; BARBERI, LAURA; COELHO, MARCELE A.; BACURAU, REURY F. P.; UGRINOWITSCH, CARLOS; MUSARO, ANTONIO; BRUM, PATRICIA C. Akt/mTOR pathway contributes to skeletal muscle anti-atrophic effect of aerobic exercise training in heart failure mice. INTERNATIONAL JOURNAL OF CARDIOLOGY, v. 214, p. 137-147, JUL 1 2016. Web of Science Citations: 9.

DOS SANTOS, MARCELO R.; SAYEGH, ANA L. C.; BACURAU, ALINE V. N.; ARAP, MARCO A.; BRUM, PATRICIA C.; PEREIRA, ROSA M. R.; TAKAYAMA, LILIAM; BARRETTO, ANTONIO C. P.; NEGRAO, CARLOS E.; DE NAZARE NUNES ALVES, MARIA JANIEIRE. Effect of Exercise Training and Testosterone Replacement on Skeletal Muscle Wasting in Patients With Heart Failure With Testosterone Deficiency. MAYO CLINIC PROCEEDINGS, v. 91, n. 5, p. 575-586, MAY 2016. Web of Science Citations: 20.

BACURAU, ALINE V.; CUNHA, TELMA F.; SOUZA, RODRIGO W.; VOLTARELLI, VANESSA A.; GABRIEL-COSTA, DANIELE; BRUM, PATRICIA C. Aerobic Exercise and Pharmacological Therapies for Skeletal Myopathy in Heart Failure: Similarities and Differences. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2016. Web of Science Citations: 8.

SOARES MELO, STEPHANO FREITAS; BARAUNA, VALERIO GARRONE; NEVES, VANDER JOSE; FERNANDES, TIAGO; LARA, LUCIENNE DA SILVA; MAZZOTTI, DIEGO ROBLES; OLIVEIRA, EDILAMAR MENEZES. Exercise training restores the cardiac microRNA-1 and-214 levels regulating Ca2+ handling after myocardial infarction. BMC CARDIOVASCULAR DISORDERS, v. 15, DEC 9 2015. Web of Science Citations: 24.

COUTO, GISELE K.; BRITT, LUIZ ROBERTO G.; MILL, JOSE G.; ROSSONI, LUCIANA V. Enhanced nitric oxide bioavailability in coronary arteries prevents the onset of heart failure in rats with myocardial infarction. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, v. 86, p. 110-120, SEP 2015. Web of Science Citations: 15.

FERNANDES, TIAGO; BARAUNA, VALERIO G.; NEGRAO, CARLOS E.; PHILLIPS, M. IAN; OLIVEIRA, EDILAMAR M. Aerobic exercise training promotes physiological cardiac remodeling involving a set of microRNAs. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 309, n. 4, p. H543-H552, AUG 15 2015. Web of Science Citations: 46.

GABRIEL-COSTA, DANIELE; DA CUNHA, TELMA FATIMA; GRASSMANN BECHARA, LUIZ ROBERTO; FORTUNATO, RODRIGO SOARES; MARCHESI BOZI, LUIZ HENRIQUE; COELHO, MARCELE DE ALMEIDA; BARRETO-CHAVES, MARIA LUIZA; BRUM, PATRICIA CHAKUR. Lactate Up-Regulates the Expression of Lactate Oxidation Complex-Related Genes in Left Ventricular Cardiac Tissue of Rats. PLoS One, v. 10, n. 5 MAY 21 2015. Web of Science Citations: 4.

GROEHS, RAPHAELA V.; TOSCHI-DIAS, EDGAR; ANTUNES-CORREA, LIGIA M.; TREVIZAN, PATRICIA F.; RONDON, MARIA URBANA P. B.; OLIVEIRA, PATRICIA; ALVES, MARIA J. N. N.; ALMEIDA, DIRCEU R.; MIDDLEKAUFF, HOLLY R.; NEGRAO, CARLOS E. Exercise training prevents the deterioration in the arterial baroreflex control of sympathetic nerve activity in chronic heart failure patients. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 308, n. 9, p. H1096-H1102, MAY 1 2015. Web of Science Citations: 14.

ALMEIDA MONTEIRO DE MORAES, WILSON MAX; MELARA, THAIS PLASTI; MORAES DE SOUZA, PAMELLA RAMONA; GUIMARAES, FABIANA DE SALVI; MARCHESI BOZI, LUIZ HENRIQUE; BRUM, PATRICIA CHAKUR; MEDEIROS, ALESSANDRA. Impact of Leucine Supplementation on Exercise Training Induced Anti-Cardiac Remodeling Effect in Heart Failure Mice. NUTRIENTS, v. 7, n. 5, p. 3751-3766, MAY 2015. Web of Science Citations: 4.

BRAGA, VIVIANE A. V. N.; COUTO, GISELE K.; LAZZARIN, MARIANA C.; ROSSONI, LUCIANA V.; MEDEIROS, ALESSANDRA. Aerobic Exercise Training Prevents the Onset of Endothelial Dysfunction via Increased Nitric Oxide Bioavailability and Reduced Reactive Oxygen Species in an Experimental Model of Menopause. PLoS One, v. 10, n. 4 APR 29 2015. Web of Science Citations: 11.

NEGRAO, CARLOS E.; MIDDLEKAUFF, HOLLY R.; GOMES-SANTOS, IGOR L.; ANTUNES-CORREA, LIGIA M. Effects of exercise training on neurovascular control and skeletal myopathy in systolic heart failure. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 308, n. 8, p. H792-H802, APR 15 2015. Web of Science Citations: 19.

SOARES MELO, STEPHANO FREITAS; BARAUNA, VALERIO GARRONE; CARNEIRO JUNIOR, MIGUEL ARAUJO; MARCHESI BOZI, LUIZ HENRIQUE; DRUMMOND, LUCAS RIOS; NATALI, ANTONIO JOSE; DE OLIVEIRA, EDILAMAR MENEZES. Resistance Training Regulates Cardiac Function through Modulation of miRNA-214. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 16, n. 4, p. 6855-6867, APR 2015. Web of Science Citations: 17.

BOUCHARD, CLAUDE; ANTUNES-CORREA, LIGIA M.; ASHLEY, EUAN A.; FRANKLIN, NINA; HWANG, PAUL M.; MATTSSON, C. MIKAEL; NEGRAO, CARLOS E.; PHILLIPS, SHANE A.; SARZYNSKI, MARK A.; WANG, PING-YUAN; WHEELER, MATTHEW T. Personalized Preventive Medicine: Genetics and the Response to Regular Exercise in Preventive Interventionse. PROGRESS IN CARDIOVASCULAR DISEASES, v. 57, n. 4, p. 337-346, JAN-FEB 2015. Web of Science Citations: 24.

ANTUNES-CORREA, LIGIA M.; NOBRE, THAIS S.; GROEHS, RAPHAELA V.; ALVES, MARIA JANIEIRE N. N.; FERNANDES, TIAGO; COUTO, GISELE K.; RONDON, MARIA URBANA P. B.; OLIVEIRA, PATRICIA; LIMA, MARTA; MATHIAS, WILSON; BRUM, PATRICIA C.; MADY, CHARLES; ALMEIDA, DIRCEU R.; ROSSONI, LUCIANA V.; OLIVEIRA, EDILAMAR M.; MIDDLEKAUFF, HOLLY R.; NEGRAO, CARLOS E. Molecular basis for the improvement in muscle metaboreflex and mechanoreflex control in exercise-trained humans with chronic heart failure. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 307, n. 11, p. H1655-H1666, DEC 1 2014. Web of Science Citations: 27.

BECHARA, LUIZ R. G.; MOREIRA, JOSE B. N.; JANNIG, PAULO R.; VOLTARELLI, VANESSA A.; DOURADO, PAULO M.; VASCONCELOS, ANDREA R.; SCAVONE, CRISTOFORO; RAMIRES, PAULO R.; BRUM, PATRICIA C. NADPH oxidase hyperactivity induces plantaris atrophy in heart failure rats. INTERNATIONAL JOURNAL OF CARDIOLOGY, v. 175, n. 3, p. 499-507, AUG 20 2014. Web of Science Citations: 31.

VOLTARELLI, VANESSA A.; BECHARA, LUIZ R. G.; BACURAU, ALINE V. N.; MATTOS, KATT C.; DOURADO, PAULO M. M.; BUENO, JR., CARLOS R.; CASARINI, DULCE E.; NEGRAO, CARLOS E.; BRUM, PATRICIA C. Lack of beta(2)-adrenoceptors aggravates heart failure-induced skeletal muscle myopathy in mice. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v. 18, n. 6, p. 1087-1097, JUN 2014. Web of Science Citations: 10.

GOMES-SANTOS, IGOR LUCAS; FERNANDES, TIAGO; COUTO, GISELE KRUGER; AYRES FERREIRA-FILHO, JULIO CESAR; CURY SALEMI, VERA MARIA; FERNANDES, FERNANDA BARRINHA; CASARINI, DULCE ELENA; BRUM, PATRICIA CHAKUR; ROSSONI, LUCIANA VENTURINI; DE OLIVEIRA, EDILAMAR MENEZES; NEGRAO, CARLOS EDUARDO. Effects of Exercise Training on Circulating and Skeletal Muscle Renin-Angiotensin System in Chronic Heart Failure Rats. PLoS One, v. 9, n. 5 MAY 23 2014. Web of Science Citations: 32.

BRUM, P. C.; BACURAU, A. V.; CUNHA, T. F.; BECHARA, L. R. G.; MOREIRA, J. B. N. Skeletal myopathy in heart failure: effects of aerobic exercise training. Experimental Physiology, v. 99, n. 4, p. 616-620, APR 1 2014. Web of Science Citations: 14.

JANNIG, PAULO R.; MOREIRA, JOSE B. N.; BECHARA, LUIZ R. G.; BOZI, LUIZ H. M.; BACURAU, ALINE V.; MONTEIRO, ALEX W. A.; DOURADO, PAULO M.; WISLOFF, ULRIK; BRUM, PATRICIA C. Autophagy Signaling in Skeletal Muscle of Infarcted Rats. PLoS One, v. 9, n. 1 JAN 10 2014. Web of Science Citations: 31.

MELO, STEPHANO F. S.; FERNANDES, TIAGO; BARAUNA, VALERIO G.; MATOS, KATT C.; SANTOS, ALEXANDRA A. S.; TUCCI, PAULO J. F.; OLIVEIRA, EDILAMAR M. Expression of MicroRNA-29 and Collagen in Cardiac Muscle after Swimming Training in Myocardial-Infarcted Rats. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 33, n. 3, p. 657-669, 2014. Web of Science Citations: 42.

ALVES, CLEBER RENE; ALVES, GUILHERME BARRETO; PEREIRA, ALEXANDRE COSTA; TROMBETTA, IVANI CREDIDIO; DIAS, RODRIGO GONCALVES; MOTA, GLORIA F. A.; FERNANDES, TIAGO; KRIEGER, JOSE EDUARDO; NEGRAO, CARLOS EDUARDO; OLIVEIRA, EDILAMAR MENEZES. Vascular reactivity and ACE activity response to exercise training are modulated by the+9/-9 bradykinin B-2 receptor gene functional polymorphism. Physiological Genomics, v. 45, n. 12, p. 487-492, JUN 2013. Web of Science Citations: 7.

VANZELLI, ANDREA S.; MEDEIROS, ALESSANDRA; ROLIM, NATALE; BARTHOLOMEU, JAN B.; CUNHA, TELMA F.; BECHARA, LUIZ G.; GOMES, ENEAS R. M.; MATTOS, KATT C.; SIRVENTE, RAQUEL; SALEMI, VERA; MADY, CHARLES; NEGRAO, CARLOS E.; GUATIMOSIM, SILVIA; BRUM, PATRICIA C. Integrative Effect of Carvedilol and Aerobic Exercise Training Therapies on Improving Cardiac Contractility and Remodeling in Heart Failure Mice. PLoS One, v. 8, n. 5 MAY 1 2013. Web of Science Citations: 15.

MOREIRA, JOSE B. N.; BECHARA, LUIZ R. G.; BOZI, LUIZ H. M.; JANNIG, PAULO R.; MONTEIRO, ALEX W. A.; DOURADO, PAULO M.; WISLOFF, ULRIK; BRUM, PATRICIA C. High- versus moderate-intensity aerobic exercise training effects on skeletal muscle of infarcted rats. Journal of Applied Physiology, v. 114, n. 8, p. 1029-1041, APR 2013. Web of Science Citations: 46.

TOSCHI-DIAS, EDGAR; TROMBETTA, IVANI C.; DIAS DA SILVA, VALDO JOSE; MAKI-NUNES, CRISTIANE; ALVES, MARIA JANIEIRE N. N.; ANGELO, LUCIANA F.; CEPEDA, FELIPE X.; MARTINEZ, DANIEL G.; NEGRAO, CARLOS EDUARDO; RONDON, MARIA URBANA P. B. Symptoms of anxiety and mood disturbance alter cardiac and peripheral autonomic control in patients with metabolic syndrome. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, v. 113, n. 3, p. 671-679, MAR 2013. Web of Science Citations: 6.

ZAGLIA, TANIA; MILAN, GIULIA; FRANZOSO, MAURO; BERTAGGIA, ENRICO; PIANCA, NICOLA; PIASENTINI, ELEONORA; VOLTARELLI, VANESSA A.; CHIAVEGATO, DAVID; BRUM, PATRICIA C.; GLASS, DAVID J.; SCHIAFFINO, STEFANO; SANDRI, MARCO; MONGILLO, MARCO. Cardiac sympathetic neurons provide trophic signal to the heart via 2-adrenoceptor-dependent regulation of proteolysis. Cardiovascular Research, v. 97, n. 2, p. 240-250, FEB 2013. Web of Science Citations: 33.