Cellular and functional bases of exercise in cardiovascular diseases

• Grant number: 10/50048-1
• Support Opportunities: Research Projects - Thematic Grants
• Start date: August 01, 2010
• End date: January 31, 2016
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Carlos Eduardo Negrão
• Grantee: Carlos Eduardo Negrão
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• City of the host institution: São Paulo
• Principal investigators: Antonio Carlos Pereira-Barretto ; Edilamar Menezes de Oliveira ; Luciana Venturini Rossoni ; Maria Urbana Pinto Brandão Rondon ; Patricia Chakur Brum
• Associated research grant(s): 14/22335-7 - Study of perivascular innervation in arteries from post-myocardial infarction rats: effect of physical training, AV.EXT
• Associated scholarship(s): 14/13690-8 - Role of exercise training on prevention of cardiotoxicity provoked by doxorubicin, BP.PD; 13/10472-7 - Swimming exercise training in vascular remodeling of coronary arteries of spontaneously hypertensive rats: effects on the expression of microRNAs and perspective of identifying therapeutic targets., BP.PD

Abstract

Accumulated evidences show that exercise training plays an important role in cardiovascular disease. The present study will focus on the effects that exercise training may have on muscle mechanoreflex and metaboreflex controls of sympathetic nerve activity in patients with heart failure. In addition, we will investigate the cellular mechanisms involved in these controls. At a vascular level, we will study the effects of exercise training on miRNA expression involved in the cardiac angiogenesis in spontaneously hypertensive rats. Also, we will investigate the influence of exercise training on pro-inflammation, oxidative stress and antioxidant enzymes in endothelial cells of the human femoral artery, and on the vascular morphology and function of animals with heart failure. The final section will be dedicated to the investigation of the effects of exercise training on cardiac remodeling and skeletal myopathy in heart failure. To accomplish this goal, we will study the effects of exercise training on cardiac calcineurine pathway and skeletal muscle protein synthesis and degradation with two different approaches: heart failure patients submitted to cardiac resynchronization therapy and heart failure patients undergoing testosterone therapy. Furthermore, we will study the role of angiotensin II on the amelioration of muscle myopathy provoked by exercise training. Finally, we close this section investigating if the improvement of cardiac and skeletal myopathy in heart failure is associated with exercise training intensity. (AU)

Scientific publications

(64)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

SOARES MELO, STEPHANO FREITAS; BARAUNA, VALERIO GARRONE; CARNEIRO JUNIOR, MIGUEL ARAUJO; MARCHESI BOZI, LUIZ HENRIQUE; DRUMMOND, LUCAS RIOS; NATALI, ANTONIO JOSE; DE OLIVEIRA, EDILAMAR MENEZES. Resistance Training Regulates Cardiac Function through Modulation of miRNA-214. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 16, n. 4, p. 6855-6867, APR 2015. (10/50048-1, 10/09438-0, 09/18370-3)

BOZI, LUIZ H. M.; JANNIG, PAULO R.; ROLIM, NATALE; VOLTARELLI, VANESSA A.; DOURADO, PAULO M. M.; WISLOFF, ULRIK; BRUM, PATRICIA C.. Aerobic exercise training rescues cardiac protein quality control and blunts endoplasmic reticulum stress in heart failure rats. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v. 20, n. 11, p. 2208-2212, NOV 2016. (10/50048-1, 14/23703-0)

VOLTARELLI, VANESSA A.; BECHARA, LUIZ R. G.; BACURAU, ALINE V. N.; MATTOS, KATT C.; DOURADO, PAULO M. M.; BUENO, JR., CARLOS R.; CASARINI, DULCE E.; NEGRAO, CARLOS E.; BRUM, PATRICIA C.. Lack of beta(2)-adrenoceptors aggravates heart failure-induced skeletal muscle myopathy in mice. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v. 18, n. 6, p. 1087-1097, JUN 2014. (10/50048-1, 08/56483-1)

FERNANDES, TIAGO; MAGALHAES, FLAVIO DE CASTRO; DO CARMO, EVERTON CRIVOI; DE OLIVEIRA, EDILAMAR MENEZES. O treinamento físico aeróbio inibe a sinalização apoptótica muscular esquelética mediada por VEGF-VEGR2 em ratos espontaneamente hipertensos. Revista Brasileira de Medicina do Esporte, v. 18, n. 6, p. 412-418, NOV-DEC 2012. (10/50048-1)

TOSCHI-DIAS, EDGAR; TROMBETTA, IVANI C.; DIAS DA SILVA, VALDO JOSE; MAKI-NUNES, CRISTIANE; ALVES, MARIA JANIEIRE N. N.; ANGELO, LUCIANA F.; CEPEDA, FELIPE X.; MARTINEZ, DANIEL G.; NEGRAO, CARLOS EDUARDO; RONDON, MARIA URBANA P. B.. Symptoms of anxiety and mood disturbance alter cardiac and peripheral autonomic control in patients with metabolic syndrome. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, v. 113, n. 3, p. 671-679, MAR 2013. (08/03714-6, 10/50048-1)

FERNANDES, TIAGO; MAGALHAES, FLAVIO DE CASTRO; DO CARMO, EVERTON CRIVOI; DE OLIVEIRA, EDILAMAR MENEZES. AEROBIC EXERCISE TRAINING INHIBITS SKELETAL MUSCULAR APOPTOTIC SIGNALING MEDIATED BY VEGF-VEGR2 IN SPONTANEOUSLY HYPERTENSIVE RATS. Revista Brasileira de Medicina do Esporte, v. 18, n. 6, p. 7-pg., 2012-11-01. (10/50048-1)

FERNANDES, TIAGO; BARRETTI, DIEGO LOPES; PHILLIPS, M. IAN; OLIVEIRA, EDILAMAR MENEZES. Exercise training prevents obesity-associated disorders: Role of miRNA-208a and MED13. Molecular and Cellular Endocrinology, v. 476, p. 148-154, NOV 15 2018. (14/50673-4, 10/50048-1, 15/17275-8, 09/18370-3)

DARDI, PATRIZIA; FERREIRA DOS REIS COSTA, DANIELA ESTEVES; REIS ASSUNCAO, HENRIQUE CHARLANTI; ROSSONI, LUCIANA VENTURINI. Venous endothelial function in cardiovascular disease. BIOSCIENCE REPORTS, v. 42, n. 11, p. 16-pg., 2022-11-01. (20/10381-5, 19/08026-5, 10/50048-1, 21/04234-2)

NOBRE, T. S.; GROEHS, R. V.; AZEVEDO, L. F.; ANTUNES-CORREA, L. M.; MARTINEZ, D. G.; ALVES, M. J. N. N.; NEGRAO, C. E.. Post-Exercise Neurovascular Control in Chronic Heart Failure Patients. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, v. 37, n. 13, p. 1073-1079, DEC 2016. (10/50048-1)

BOUCHARD, CLAUDE; ANTUNES-CORREA, LIGIA M.; ASHLEY, EUAN A.; FRANKLIN, NINA; HWANG, PAUL M.; MATTSSON, C. MIKAEL; NEGRAO, CARLOS E.; PHILLIPS, SHANE A.; SARZYNSKI, MARK A.; WANG, PING-YUAN; et al. Personalized Preventive Medicine: Genetics and the Response to Regular Exercise in Preventive Interventionse. PROGRESS IN CARDIOVASCULAR DISEASES, v. 57, n. 4, p. 337-346, JAN-FEB 2015. (10/50048-1, 13/15651-7, 13/07607-8)

DOS SANTOS, MARCELO R.; SAYEGH, ANA L. C.; BACURAU, ALINE V. N.; ARAP, MARCO A.; BRUM, PATRICIA C.; PEREIRA, ROSA M. R.; TAKAYAMA, LILIAM; BARRETTO, ANTONIO C. P.; NEGRAO, CARLOS E.; DE NAZARE NUNES ALVES, MARIA JANIEIRE. Effect of Exercise Training and Testosterone Replacement on Skeletal Muscle Wasting in Patients With Heart Failure With Testosterone Deficiency. MAYO CLINIC PROCEEDINGS, v. 91, n. 5, p. 575-586, MAY 2016. (10/50048-1)

MELO, STEPHANO F. S.; FERNANDES, TIAGO; BARAUNA, VALERIO G.; MATOS, KATT C.; SANTOS, ALEXANDRA A. S.; TUCCI, PAULO J. F.; OLIVEIRA, EDILAMAR M.. Expression of MicroRNA-29 and Collagen in Cardiac Muscle after Swimming Training in Myocardial-Infarcted Rats. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 33, n. 3, p. 657-669, 2014. (10/50048-1, 10/09438-0, 09/18370-3)

BRAGA, VIVIANE A. V. N.; COUTO, GISELE K.; LAZZARIN, MARIANA C.; ROSSONI, LUCIANA V.; MEDEIROS, ALESSANDRA. Aerobic Exercise Training Prevents the Onset of Endothelial Dysfunction via Increased Nitric Oxide Bioavailability and Reduced Reactive Oxygen Species in an Experimental Model of Menopause. PLoS One, v. 10, n. 4, APR 29 2015. (12/17709-0, 10/50048-1)

NEGRAO, CARLOS E.; MIDDLEKAUFF, HOLLY R.; GOMES-SANTOS, IGOR L.; ANTUNES-CORREA, LIGIA M.. Effects of exercise training on neurovascular control and skeletal myopathy in systolic heart failure. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 308, n. 8, p. H792-H802, APR 15 2015. (10/50048-1, 13/15651-7, 14/13690-8)

COUTO, GISELE K.; BRITT, LUIZ ROBERTO G.; MILL, JOSE G.; ROSSONI, LUCIANA V.. Enhanced nitric oxide bioavailability in coronary arteries prevents the onset of heart failure in rats with myocardial infarction. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, v. 86, p. 110-120, SEP 2015. (10/50048-1)

GROEHS, RAPHAELA V.; TOSCHI-DIAS, EDGAR; ANTUNES-CORREA, LIGIA M.; TREVIZAN, PATRICIA F.; RONDON, MARIA URBANA P. B.; OLIVEIRA, PATRICIA; ALVES, MARIA J. N. N.; ALMEIDA, DIRCEU R.; MIDDLEKAUFF, HOLLY R.; NEGRAO, CARLOS E.. Exercise training prevents the deterioration in the arterial baroreflex control of sympathetic nerve activity in chronic heart failure patients. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 308, n. 9, p. H1096-H1102, MAY 1 2015. (10/50048-1, 13/15651-7, 13/07651-7)

GABRIEL-COSTA, DANIELE; DA CUNHA, TELMA FATIMA; GRASSMANN BECHARA, LUIZ ROBERTO; FORTUNATO, RODRIGO SOARES; MARCHESI BOZI, LUIZ HENRIQUE; COELHO, MARCELE DE ALMEIDA; BARRETO-CHAVES, MARIA LUIZA; BRUM, PATRICIA CHAKUR. Lactate Up-Regulates the Expression of Lactate Oxidation Complex-Related Genes in Left Ventricular Cardiac Tissue of Rats. PLoS One, v. 10, n. 5, MAY 21 2015. (10/50048-1)

SOARES MELO, STEPHANO FREITAS; BARAUNA, VALERIO GARRONE; NEVES, VANDER JOSE; FERNANDES, TIAGO; LARA, LUCIENNE DA SILVA; MAZZOTTI, DIEGO ROBLES; OLIVEIRA, EDILAMAR MENEZES. Exercise training restores the cardiac microRNA-1 and-214 levels regulating Ca2+ handling after myocardial infarction. BMC CARDIOVASCULAR DISORDERS, v. 15, DEC 9 2015. (10/50048-1, 10/09438-0, 12/04104-2, 09/18370-3)

DOS SANTOS, MARCELO RODRIGUES; CARRARI SAYEGH, ANA LUIZA; RAMALHO GROEHS, RAPHAELA VILAR; FONSECA, GUILHERME; TROMBETTA, IVANI CREDIDIO; PEREIRA BARRETTO, ANTONIO CARLOS; ARAP, MARCO ANTONIO; NEGRAO, CARLOS EDUARDO; MIDDLEKAUFF, HOLLY R.; NUNES ALVES, MARIA-JANIEIRE DE NAZARE. . Arquivos Brasileiros de Cardiologia, v. 105, n. 3, p. 256-264, SEP 2015. (10/50048-1)

ANTUNES-CORREA, LIGIA M.; NOBRE, THAIS S.; GROEHS, RAPHAELA V.; ALVES, MARIA JANIEIRE N. N.; FERNANDES, TIAGO; COUTO, GISELE K.; RONDON, MARIA URBANA P. B.; OLIVEIRA, PATRICIA; LIMA, MARTA; MATHIAS, WILSON; et al. Molecular basis for the improvement in muscle metaboreflex and mechanoreflex control in exercise-trained humans with chronic heart failure. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 307, n. 11, p. H1655-H1666, DEC 1 2014. (10/50048-1)

GRAZIELA AMARO-VICENTE; MATEUS C. LATERZA; DANIEL G. MARTINEZ; MARIA JANIEIRE N. N. ALVES; IVANI C. TROMBETTA; ANA MARIA F. W. BRAGA; EDGAR TOSCHI-DIAS; MARIA URBANA P. B. RONDON. Exercise Training Improves Heart Rate Recovery after Exercise in Hypertension. Motriz: rev. educ. fis., v. 25, n. 1, 2019-08-22. (10/50048-1)

COUTO, GISELE K.; PAULA, SULIANA M.; GOMES-SANTOS, IGOR L.; NEGRAO, CARLOS EDUARDO; ROSSONI, V, LUCIANA. Exercise training induces eNOS coupling and restores relaxation in coronary arteries of heart failure rats. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 314, n. 4, p. H878-H887, APR 2018. (10/50048-1)

TOSCHI-DIAS, EDGAR; TROMBETTA, IVANI C.; SILVA, VALDO J. D.; MAKI-NUNES, CRISTIANE; CEPEDA, FELIPE X.; ALVES, MARIA JANIEIRE N. N.; CARVALHO, GLAUCE L.; DRAGER, LUCIANO F.; LORENZI-FILHO, GERALDO; NEGRAO, CARLOS E.; et al. Diet associated with exercise improves baroreflex control of sympathetic nerve activity in metabolic syndrome and sleep apnea patients. Sleep and Breathing, v. 23, n. 1, p. 143-151, MAR 2019. (08/03714-6, 12/02953-2, 16/16831-7, 13/07651-7, 11/17533-6, 10/50048-1)

FERREIRA-SANTOS, LARISSA; MARTINEZ, DANIEL G.; NICOLAU, JOSE CARLOS; MOREIRA, HUMBERTO G.; ALVES, MARIA JANIEIRE; PEREIRA, ALEXANDRE C.; TROMBETTA, IVANI C.; NEGRAO, CARLOS EDUARDO; RONDON, MARIA URBANA P. B.. Neurovascular control during exercise in acute coronary syndrome patients with Gln27Glu polymorphism of beta(2)-adrenergic receptor. PLoS One, v. 12, n. 2, FEB 24 2017. (10/50048-1, 05/59740-7)

NOBRE, THAIS S.; ANTUNES-CORREA, LIGIA M.; GROEHS, RAPHAELA V.; ALVES, MARIA JANIEIRE N. N.; SARMENTO, ADRIANA O.; BACURAU, ALINE V.; URIAS, URSULA; ALVES, GUILHERME B.; RONDON, MARIA URBANA P. B.; BRUM, PATRICIA C.; et al. Exercise training improves neurovascular control and calcium cycling gene expression in patients with heart failure with cardiac resynchronization therapy. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 311, n. 5, p. H1180-H1188, NOV 2016. (10/50048-1)

LOBO, DENISE M. L.; TREVIZAN, PATRICIA F.; TOSCHI-DIAS, EDGAR; OLIVEIRA, PATRICIA A.; PIVETA, RAFAEL B.; ALMEIDA, DIRCEU R.; MADY, CHARLES; BOCCHI, EDIMAR A.; LORENZI-FILHO, GERALDO; MIDDLEKAUFF, HOLLY R.; et al. Sleep-Disordered Breathing Exacerbates Muscle Vasoconstriction and Sympathetic Neural Activation in Patients with Systolic Heart Failure. Circulation-Heart Failure, v. 9, n. 11, NOV 2016. (10/50048-1, 13/07651-7)

DARDI, PATRIZIA; PERAZZA, LAIS ROSSI; COUTO, GISELE KRUGER; CAMPOS, GIANNE PAUL; AGGUM CAPETTINI, LUCIANO DOS SANTOS; ROSSONI, LUCIANA VENTURINI. ena cava presents endothelial dysfunction prior to thoracic aorta in heart failure: the pivotal role of nNOS uncoupling/oxidative stres. Clinical Science, v. 135, n. 23, p. 2625-2641, DEC 2021. (10/50048-1)

FERNANDES, TIAGO; ROQUE, FERNANDA ROBERTA; MAGALHAES, FLAVIO DE CASTRO; DO CARMO, EVERTON CRIVOI; DE OLIVEIRA, EDILAMAR MENEZES. . Revista Brasileira de Medicina do Esporte, v. 18, n. 4, p. 267-272, JUL-AUG 2012. (10/50048-1, 09/18370-3)

BECHARA, LUIZ R. G.; MOREIRA, JOSE B. N.; JANNIG, PAULO R.; VOLTARELLI, VANESSA A.; DOURADO, PAULO M.; VASCONCELOS, ANDREA R.; SCAVONE, CRISTOFORO; RAMIRES, PAULO R.; BRUM, PATRICIA C.. NADPH oxidase hyperactivity induces plantaris atrophy in heart failure rats. INTERNATIONAL JOURNAL OF CARDIOLOGY, v. 175, n. 3, p. 499-507, AUG 20 2014. (10/50048-1)

VANZELLI, ANDREA S.; MEDEIROS, ALESSANDRA; ROLIM, NATALE; BARTHOLOMEU, JAN B.; CUNHA, TELMA F.; BECHARA, LUIZ G.; GOMES, ENEAS R. M.; MATTOS, KATT C.; SIRVENTE, RAQUEL; SALEMI, VERA; et al. Integrative Effect of Carvedilol and Aerobic Exercise Training Therapies on Improving Cardiac Contractility and Remodeling in Heart Failure Mice. PLoS One, v. 8, n. 5, MAY 1 2013. (10/50048-1)

VOLTARELLI, VANESSA A.; BECHARA, LUIZ R. G.; BACURAU, ALINE V. N.; MATTOS, KATT C.; DOURADO, PAULO M. M.; BUENO, CARLOS R., JR.; CASARINI, DULCE E.; NEGRAO, CARLOS E.; BRUM, PATRICIA C.. Lack of beta(2)-adrenoceptors aggravates heart failure-induced skeletal muscle myopathy in mice. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v. 18, n. 6, p. 11-pg., 2014-06-01. (08/56483-1, 10/50048-1)

TOSCHI-DIAS, EDGAR; MONTANO, NICOLA; TOBALDINI, ELEONORA; TREVIZAN, PATRICIA F.; GROEHS, V, RAPHAELA; ANTUNES-CORREA, LIGIA M.; NOBRE, THAIS S.; LOBO, DENISE M.; SALES, ALLAN R. K.; UENO-PARDI, LINDA M.; et al. Oscillatory Pattern of Sympathetic Nerve Bursts Is Associated With Baroreflex Function in Heart Failure Patients With Reduced Ejection Fraction. FRONTIERS IN NEUROSCIENCE, v. 15, AUG 31 2021. (10/50048-1, 15/17642-0, 13/07651-7, 15/22814-5)

BERNAK-OLIVEIRA, ANGELO; GUIZONI, DANIELE M.; CHIAVEGATTO, SILVANA; DAVEL, ANA P.; V. ROSSONI, LUCIANA. The protective role of neuronal nitric oxide synthase in endothelial vasodilation in chronic beta-adrenoceptor overstimulation. Life Sciences, v. 285, NOV 15 2021. (10/50048-1, 11/16017-4, 17/06100-8)

BACURAU, ALINE V.; CUNHA, TELMA F.; SOUZA, RODRIGO W.; VOLTARELLI, VANESSA A.; GABRIEL-COSTA, DANIELE; BRUM, PATRICIA C.. Aerobic Exercise and Pharmacological Therapies for Skeletal Myopathy in Heart Failure: Similarities and Differences. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, v. 2016, p. 16-pg., 2016-01-01. (10/50048-1, 14/25957-9)

LOBO, DENISE M. L.; TREVIZAN, PATRICIA F.; TOSCHI-DIAS, EDGAR; OLIVEIRA, PATRICIA A.; PIVETA, RAFAEL B.; MADY, CHARLES; BOCCHI, EDIMAR A.; ALMEIDA, DIRCEU R.; LORENZI-FILHO, GERALD; MIDDLEKAUFF, HOLLY R.; et al. Sleep Apnea Worsens Muscle Vasoconstriction During Central and Peripheral Chemoreceptors Stimulation in Patients with Systolic Heart Failure. FASEB JOURNAL, v. 30, p. 2-pg., 2016-04-01. (10/50048-1)

BOZI, LUIZ H. M.; JANNIG, PAULO R.; ROLIM, NATALE; VOLTARELLI, VANESSA A.; DOURADO, PAULO M. M.; WISLOFF, ULRIK; BRUM, PATRICIA C.. Aerobic exercise training rescues cardiac protein quality control and blunts endoplasmic reticulum stress in heart failure rats. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v. 20, n. 11, p. 5-pg., 2016-11-01. (14/23703-0, 10/50048-1)

FERREIRA-SANTOS, LARISSA; MARTINEZ, DANIEL GODOY; NICOLAU, JOSE CARLOS; MOREIRA, HUMBERTO GRANER; ALVES, MARIA JANIEIRE N. N.; TROMBETTA, IVANI CREDIDIO; NEGRAO, CARLOS EDUARDO; RONDON, MARIA URBANA P. B.. Effect of Exercise Training on Neurovascular Control During Mental Stress in Patients with Acute Coronary Syndrome. FASEB JOURNAL, v. 31, p. 1-pg., 2017-04-01. (10/50048-1)

SOARES MELO, STEPHANO FREITAS; BARAUNA, VALERIO GARRONE; CARNEIRO JUNIOR, MIGUEL ARAUJO; MARCHESI BOZI, LUIZ HENRIQUE; DRUMMOND, LUCAS RIOS; NATALI, ANTONIO JOSE; DE OLIVEIRA, EDILAMAR MENEZES. Resistance Training Regulates Cardiac Function through Modulation of miRNA-214. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 16, n. 4, p. 13-pg., 2015-04-01. (10/09438-0, 09/18370-3, 10/50048-1)

BACURAU, ALINE V.; CUNHA, TELMA F.; SOUZA, RODRIGO W.; VOLTARELLI, VANESSA A.; GABRIEL-COSTA, DANIELE; BRUM, PATRICIA C.. Aerobic Exercise and Pharmacological Therapies for Skeletal Myopathy in Heart Failure: Similarities and Differences. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2016. (14/25957-9, 10/50048-1)

SILVEIRA, ANDRE C.; FERNANDES, TIAGO; SOCI, URSULA P. R.; GOMES, JOAO L. P.; BARRETTI, DIEGO L.; MOTA, GLORIA G. F.; NEGRAO, CARLOS EDUARDO; OLIVEIRA, EDILAMAR M.. Exercise Training Restores Cardiac MicroRNA-1 and MicroRNA-29c to Nonpathological Levels in Obese Rats. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2017. (10/50048-1, 13/07607-8, 09/18370-3)

ALVES, CLEBER RENE; FERNANDES, TIAGO; LEMOS, JR., JOSE RIBEIRO; MAGALHAES, FLAVIO DE CASTRO; TROMBETTA, IVANI CREDIDIO; ALVES, GUILHERME BARRETO; ALVES DA MOTA, GLORIA DE FATIMA; DIAS, RODRIGO GONCALVES; PEREIRA, ALEXANDRE COSTA; KRIEGER, JOSE EDUARDO; et al. Aerobic exercise training differentially affects ACE C- and N-domain activities in humans: Interactions with ACE I/D polymorphism and association with vascular reactivity. JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, v. 19, n. 2, APR 9 2018. (10/50048-1, 09/18370-3)

PAULA, SULIANA M.; COUTO, GISELE K.; FONTES, MILENE T.; COSTA, SORAIA K.; NEGRAO, CARLOS E.; MILL, JOSE G.; ROSSONI, V, LUCIANA. Exercise training restores the myogenic response in skeletal muscle resistance arteries and corrects peripheral edema in rats with heart failure. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 317, n. 1, p. H87-H96, JUL 2019. (10/50048-1)

SARMENTO, ADRIANA OLIVEIRA; ANTUNES-CORREA, LIGIA M.; ALVES, MARIA J. N. N.; BACURAU, ALINE V. N.; FONSECA, KEILA C. B.; PESSOA, FERNANDA G.; LOBO, DENISE M. L.; MOREIRA, LEILA D. P.; TROMBETTA, IVANI C.; RONDON, MARIA U. P. B.; et al. Effect of exercise training on cardiovascular autonomic and muscular function in subclinical Chagas cardiomyopathy: a randomized controlled trial. CLINICAL AUTONOMIC RESEARCH, v. 31, n. 2, SEP 2020. (13/15651-7, 11/17533-6, 10/50048-1)

FERNANDES, TIAGO; CASAES, LILIAN; SOCI, URSULA; SILVEIRA, ANDRE; GOMES, JOAO; BARRETTI, DIEGO; ROQUE, FERNANDA; OLIVEIRA, EDILAMAR. Exercise Training Restores the Cardiac Microrna-16 Levels Preventing Microvascular Rarefaction in Obese Zucker Rats. Obesity Facts, v. 11, n. 1, p. 15-24, 2018. (14/50673-4, 10/50048-1, 15/17275-8, 09/18370-3)

BLANCO-RIVERO, JAVIER; COUTO, GISELE K.; PAULA, SULIANA M.; FONTES, MILENE T.; ROSSONI, V, LUCIANA. Enhanced sympathetic neurotransduction in the superior mesenteric artery in a rat model of heart failure: role of noradrenaline and ATP. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 320, n. 2, p. H563-H574, FEB 2021. (10/50048-1, 14/20303-0, 14/22335-7)

DAS NEVES, VANDER JOSE; FERNANDES, TIAGO; ROQUE, FERNANDA ROBERTA; RENO SOCI, URSULA PAULA; SOARES MELO, STEPHANO FREITAS; DE OLIVEIRA, EDILAMAR MENEZES. Exercise training in hypertension: Role of microRNAs. WORLD JOURNAL OF CARDIOLOGY, v. 6, n. 8, p. 15-pg., 2014-08-26. (10/50048-1, 13/10472-7, 10/09438-0, 12/04104-2)

ROQUE, FERNANDA ROBERTA; CHO, HENRIQUE; FERNANDES, TIAGO; DAS NEVES, VANDER JOSE; ALVES DA MOTA, GLORIA DE FATIMA; ROSSONI, LUCIANA VENTURINI; DE OLIVEIRA, EDILAMAR MENEZES. -Aerobic Swimming Training Changes Coronary Vascular Remodeling and MicroRNA Expression in Spontaneously Hypertensive Rats (SHR)-. FASEB JOURNAL, v. 30, p. 2-pg., 2016-04-01. (13/10472-7, 10/50048-1)

GROEHS, RAPHAELA V.; ANTUNES-CORREA, LIGIA M.; NOBRE, THAIS S.; ALVES, MARIA-JANIEIRE N. N.; RONDON, MARIA URBANA P. B.; PEREIRA BARRETO, ANTONIO CARLOS; NEGRAO, CARLOS E.. Muscle electrical stimulation improves neurovascular control and exercise tolerance in hospitalised advanced heart failure patients. EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, v. 23, n. 15, p. 1599-1608, OCT 2016. (10/50048-1, 13/15651-7)

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