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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The influence of aetiology on the benefits of exercise training in patients with heart failure

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Author(s):
Antunes-Correa, Ligia M. ; Ueno-Pardi, Linda M. ; Trevizan, Patricia F. ; Santos, Marcelo R. ; da Silva, Carlos Henrique P. ; Franco, Fabio G. M. ; Alves, Maria Janieire N. N. ; Rondon, Maria Urbana P. B. ; Negrao, Carlos E.
Total Authors: 9
Document type: Journal article
Source: EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY; v. 24, n. 4, p. 365-372, MAR 2017.
Web of Science Citations: 7
Abstract

Background: Exercise training improves neurovascular control and functional capacity in heart failure (HF) patients. However, the influence of the aetiology on these benefits is unknown. We compared the effects of exercise training on neurovascular control and functional capacity in idiopathic, ischaemic and hypertensive HF patients. Design: Subjects consisted of 45 exercise-trained HF patients from our database (2000-2015), aged 40-70 years old, functional class II/ III and ejection fraction <= 40%, and they were divided into three groups: idiopathic (n = 11), ischaemic (n = 18) and hypertensive (n = 16). Methods: Functional capacity was determined by cardiopulmonary exercise testing. Muscle sympathetic nerve activity (MSNA) was recorded by microneurography. Forearm blood flow (FBF) was measured by venous occlusion plethysmography. Results: Four months of exercise training significantly reduced MSNA and significantly increased FBF in all groups. However, the relative reduction in MSNA was greater in hypertensive patients compared with that in idiopathic patients (frequency: -34% vs. -15%, p -0.01; incidence: -31% vs. -12%, p -0.02). No differences were found between hypertensive patients and ischaemic patients. The relative increase in FBF was greater in hypertensive patients than in ischaemic and idiopathic patients (42% vs. 15% and 17%, respectively, p = 0.02). The relative increase in forearm vascular conductance was greater in hypertensive patients compared with those in ischaemic and idiopathic patients (57% vs. 13% and 26%, respectively, p = 0.001). Exercise training significantly and similarly increased peak oxygen consumption in all groups. Conclusion: The exercise-induced improvement in neurovascular control is more pronounced in hypertensive HF patients than in idiopathic and ischaemic HF patients. The increase in functional capacity is independent of aetiology. (AU)

FAPESP's process: 13/15651-7 - Effects of aerobic exercise training associated with inspiratory muscle training on skeletal myopathy in patients with heart failure
Grantee:Lígia de Moraes Antunes Corrêa
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 10/50048-1 - Cellular and functional bases of exercise in cardiovascular diseases
Grantee:Carlos Eduardo Negrão
Support type: Research Projects - Thematic Grants