Effect of interval versus continuous training on function sympathetic and peripheral infusion in patients with heart failure: a randomized study with control groups

• Grant number: 10/08990-1
• Support type: Regular Research Grants
• Duration: August 01, 2010 - January 31, 2013
• Field of knowledge: Biological Sciences - Physiology - Physiology of Effort
• Principal researcher: Guilherme Veiga Guimarães
• Grantee: Guilherme Veiga Guimarães
• Home Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

The physiopathology of the heart failure involves compensatory mechanisms as exacerbated neurohormonal activity, endothelial dysfunction and consequently the muscle disability and exercise intolerance. The interval exercise training has been proposed as one efficient method to heart failure patients. It seems that the main mechanism involved in the benefit of the interval exercise training is the "shear stress". AIM: To study the interval exercise training versus the continuous exercise training in the sympathetic activity and in the peripheral muscle perfusion in heart failure patients. Moreover, we will evaluate the muscle apoptosis, levels of antioxidants enzymes, quality of life and exercise capacity. METODOLOGY: Will be selected 27 patients (male and female) with age between 40 and 60 years, left ventricular ejection fraction less than 40% and functional class I, II and III. These patients will be randomized into three groups: Interval (GI), continuous (GC) and control (GE). All patients will be evaluated with microneurography, peripheral muscle perfusion, muscle biopsy, cardiopulmonary exercise test and quality of life before and after end of the period of 02 (two) months. This way, we expect evaluate the impact of the interval exercise training versus continuous exercise training in the sympathetic activity and in the peripheral muscle perfusion in heart failure patients. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERNANDES-SILVA, MIGUEL M.; GUIMARAES, GUILHERME V.; RIGAUD, VAGNER O. C.; LOFRANO-ALVES, MARCO S.; CASTRO, RAFAEL E.; DE BARROS CRUZ, LAIS G.; BOCCHI, EDIMAR A.; BACAL, FERNANDO. Inflammatory biomarkers and effect of exercise on functional capacity in patients with heart failure: Insights from a randomized clinical trial. EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, v. 24, n. 8, p. 808-817, MAY 2017. (10/08990-1, 11/00640-4)

SALES, ALLAN R. K.; AZEVEDO, LUCIENE F.; SILVA, THIAGO O. C.; RODRIGUES, AMANDA G.; OLIVEIRA, PATRICIA A.; JORDAO, CAMILA P.; ANDRADE, ANA C. M.; URIAS, URSULA; GUIMARAES, GUILHERME V.; BOCCHI, EDIMAR A.; et al. High-Intensity Interval Training Decreases Muscle Sympathetic Nerve Activity and Improves Peripheral Vascular Function in Patients With Heart Failure With Reduced Ejection Fraction. Circulation-Heart Failure, v. 13, n. 8, AUG 2020. (15/22814-5, 17/25613-6, 10/08990-1, 14/11671-6)

GUIMARAES, GUILHERME VEIGA; RIBEIRO, FERNANDO; CASTRO, RAFAEL ERTNER; ROQUE, JEAN MARCELO; TEIXEIRA MACHADO, ALEXANDER DOUGLAS; ANTUNES-CORREA, LIGIA M.; FERREIRA, SILVIA AYUB; BOCCHI, EDIMAR ALCIDES. Effects of the exercise training on skeletal muscle oxygen consumption in heart failure patients with reduced ejection fraction. INTERNATIONAL JOURNAL OF CARDIOLOGY, v. 343, NOV 15 2021. (10/08990-1)