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Role of aerobic physical training in muscle plasticity in experimental model of heart failure induced by pulmonary hypertension

Grant number: 16/24284-6
Support type:Scholarships in Brazil - Master
Effective date (Start): June 01, 2017
Effective date (End): November 30, 2019
Field of knowledge:Biological Sciences - Physiology - Physiology of Effort
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Patricia Chakur Brum
Grantee:Janaina da Silva Vieira
Home Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):18/24800-0 - Role of beta2-adrenergic receptor subpopulations on distinct response of slow and fast-twitch muscles under sympathetic hyperactivity, BE.EP.MS

Abstract

Heart failure (HF) is a clinical syndrome with high prevalence in the population and is associated with dysfunction and atrophy of skeletal muscle which together characterize the skeletal myopathy. In more advanced stages of the disease, excessive reduction of skeletal muscle mass can result in cardiac cachexia that is directly related to the poor prognosis of patients with HF. Previous studies of our group showed that animals and patients with chronic heart failure and left ventricular (LV) dysfunction have skeletal myopathy, but there is a lack of studies in the literature reporting the presence of skeletal myopathy in HF with right ventricular (RV) dysfunction. Pulmonary hypertension (PH) is a major cause of heart failure right not related to LV dysfunction, present in over 50% of the population with right HF. In recent decades it has increased the number of evidence pointing aerobic exercise training (AET) as an important component in the treatment of HF, providing metabolic and structural benefits for individuals with this syndrome. In fact, previous studies from our group demonstrated that AET minimizes skeletal myopathy in both experimental models and patients with HF with left ventricular dysfunction. However, little is known about the impact of AET in skeletal muscle in animals or patients with HF right. The monocrotaline (MCT) is known to induce HF by increased afterload on the HP resulting RV dysfunction, this model is well established and effective in rats. In mice are few studies that use the MCT model to study right HF and skeletal myopathy or the effects of AET in this syndrome. In a pilot study, we observed that treatment with MCT for 4 months was effective in causing cardiac dysfunction associated with reduced exercise tolerance. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VIEIRA, J. S.; CUNHA, T. F.; PAIXAO, N. A.; DOURADO, P. M.; CARRASCOZA, L. S.; BACURAU, A. V. N.; BRUM, P. C. Exercise intolerance establishment in pulmonary hypertension: Preventive effect of aerobic exercise training. Life Sciences, v. 261, NOV 15 2020. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.