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Cellular and molecular aspects of muscular plasticity

Abstract

Muscles are tension generators that play a key role in 1) skeleton position; 2) moving blood along the circulatory system allowing tissue perfusion; 3) venous return; 4) peripheral vascular resistance control; 5) visceral movements and 6) ocular movements. Muscle tissues are highly plastic and respond quickly to injury and hormonal stimuli. Conditions in which muscle tissues are debilitated highlight well their role in homeostatic control. For example, 1) a major cause of death in developed and developing countries is heart failure, which is commonly linked to vascular diseases, specially associated with endothelial tissue; 2) loss of skeletal muscle mass (eventually leading to cachexia) in severe cardiac failure is retated to poor prognostic; 3) loss of skeletal muscle mass over aging is an important element of the senile syndrome, where decreased immune response is a major concern. The development of new strategies aiming a better outcome of muscle function necessarily depends upon a deeper knowledge of cellular and molecular biology of tissue responses. Therefore, the aim of this study is to gain further insight on cellular and molecular mechanisms underlying muscle plasticity. In subproject 1 the effect of certain mechanical stimuli will be stressed, to further investigate the role of Akt/mTOR on skeletal muscle mass control. In subproject 2, we will address the effects of increased skeletal muscle mass upon energy balance control. This will be achieved by using muscular IGF-1 transgenic mice. In subprojects 3 and 4 we will evaluate cellular and molecular effects of hormones extremely important to the homeostasis of muscle tissues: thyroid hormone (T3) and angiotensin II. In subproject 5 a molecular approach of skeletal muscle proteolysis triggered by T3 will be performed. In subprojects 6 and 7, the activity of Akt/mTOR and calcineurin will be investigated in skeletal muscle of mice undergoing cardiac failure. Finally, in subproject 8, we will determine the effects of GC-24 (a thyroid hormone receptor β selective agonist) upon the global gene expression pattern in all three muscle tissues. (AU)

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Scientific publications (10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANTOS, A. R.; LAMAS, L.; UGRINOWITSCH, C.; TRICOLI, V.; MIYABARA, E. H.; SOARES, A. G.; AOKI, M. S. Different Resistance-Training Regimens Evoked a Similar Increase in Myostatin Inhibitors Expression. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, v. 36, n. 9, p. 761-768, AUG 2015. Web of Science Citations: 3.
BAPTISTA, IGOR L.; SILVA, WILLIAN J.; ARTIOLI, GUILHERME G.; GUILHERME, JOAO PAULO L. F.; LEAL, MARCELO L.; AOKI, MARCELO S.; MIYABARA, ELEN H.; MORISCOT, ANSELMO S. Leucine and HMB Differentially Modulate Proteasome System in Skeletal Muscle under Different Sarcopenic Conditions. PLoS One, v. 8, n. 10 OCT 4 2013. Web of Science Citations: 21.
CARRILLO-SEPULVEDA, MARIA ALICIA; CERAVOLO, GRAZIELA S.; FURSTENAU, CRISTINA R.; MONTEIRO, PRISCILLA DE SOUZA; BRUNO-FORTES, ZULEICA; CARVALHO, MARIA HELENA; LAURINDO, FRANCISCO R.; TOSTES, RITA C.; WEBB, R. CLINTON; BARRETO-CHAVES, MARIA LUIZA M. Emerging Role of Angiotensin Type 2 Receptor (AT2R)/Akt/NO Pathway in Vascular Smooth Muscle Cell in the Hyperthyroidism. PLoS One, v. 8, n. 4 APR 24 2013. Web of Science Citations: 15.
CUNHA, TELMA F.; BACURAU, ALINE V. N.; MOREIRA, JOSE B. N.; PAIXAO, NATHALIE A.; CAMPOS, JULIANE C.; FERREIRA, JULIO C. B.; LEAL, MARCELO L.; NEGRAO, CARLOS E.; MORISCOT, ANSELMO S.; WISLOFF, ULRIK; BRUM, PATRICIA C. Exercise Training Prevents Oxidative Stress and Ubiquitin-Proteasome System Overactivity and Reverse Skeletal Muscle Atrophy in Heart Failure. PLoS One, v. 7, n. 8 AUG 3 2012. Web of Science Citations: 73.
DINIZ, GABRIELA PLACONA; CREMASCO TAKANO, ANA PAULA; BRUNETO, ERIKA; DA SILVA, FRANCEMILSON GOULART; NUNES, MARIA TEREZA; MORAIS BARRETO-CHAVES, MARIA LUIZA. New insight into the mechanisms associated with the rapid effect of T-3 on AT1R expression. JOURNAL OF MOLECULAR ENDOCRINOLOGY, v. 49, n. 1, p. 11-20, AUG 2012. Web of Science Citations: 8.
LEAL, MARCELO LARCIPRETE; LAMAS, LEONARDO; AOKI, MARCELO SALDANHA; UGRINOWITSCH, CARLOS; CARNEIRO RAMOS, MARCELA SORELLI; TRICOLI, VALMOR; MORISCOT, ANSELMO SIGARI. Effect of different resistance-training regimens on the WNT-signaling pathway. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, v. 111, n. 10, SI, p. 2535-2545, OCT 2011. Web of Science Citations: 12.
BAPTISTA, IGOR L.; LEAL, MARCELO L.; ARTIOLI, GUILHERME G.; AOKI, MARCELO S.; FIAMONCINI, JARLEI; TURRI, ANTONIO O.; CURI, RUI; MIYABARA, ELEN H.; MORISCOT, ANSELMO S. LEUCINE ATTENUATES SKELETAL MUSCLE WASTING VIA INHIBITION OF UBIQUITIN LIGASES. MUSCLE & NERVE, v. 41, n. 6, p. 800-808, JUN 2010. Web of Science Citations: 66.
MORISCOT, ANSELMO S.; BAPTISTA, IGOR L.; BOGOMOLOVAS, JULIUS; WITT, CHRISTIAN; HIRNER, STEPHANIE; GRANZIER, HENK; LABEIT, SIEGFRIED. MuRF1 is a muscle fiber-type II associated factor and together with MuRF2 regulates type-II fiber trophicity and maintenance. Journal of Structural Biology, v. 170, n. 2, SI, p. 344-353, MAY 2010. Web of Science Citations: 47.
FERREIRA, JULIO C. B.; BACURAU, ALINE V.; BUENO JUNIOR, CARLOS R.; CUNHA, TELMA C.; TANAKA, LEONARDO Y.; JARDIM, MAIRA A.; RAMIRES, PAULO R.; BRUM, PATRICIA C. Aerobic exercise training improves Ca2+ handling and redox status of skeletal muscle in mice. Experimental Biology and Medicine, v. 235, n. 4, p. 497-505, APR 2010. Web of Science Citations: 37.
OLIVEIRA, R. S. F.; FERREIRA, J. C. B.; GOMES, E. R. M.; PAIXAO, N. A.; ROLIM, N. P. L.; MEDEIROS, A.; GUATIMOSIM, S.; BRUM, P. C. Cardiac anti-remodelling effect of aerobic training is associated with a reduction in the calcineurin/NFAT signalling pathway in heart failure mice. JOURNAL OF PHYSIOLOGY-LONDON, v. 587, n. 15, p. 3899-3910, AUG 1 2009. Web of Science Citations: 36.

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