Autonomic, metabolic and inflammatory aspects of metabolic syndrome associated wit...
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Symptoms of anxiety and mood disturbance alter cardiac and peripheral autonomic control in patients with metabolic syndrome
Full text
| |
| Author(s): |
Toschi-Dias, Edgar
[1]
;
Trombetta, Ivani C.
[1]
;
Dias da Silva, Valdo Jose
[2]
;
Maki-Nunes, Cristiane
[1]
;
Alves, Maria Janieire N. N.
[1]
;
Angelo, Luciana F.
[1]
;
Cepeda, Felipe X.
[1]
;
Martinez, Daniel G.
[1]
;
Negrao, Carlos Eduardo
[3, 1]
;
Rondon, Maria Urbana P. B.
[1, 3]
Total Authors: 10
|
| Affiliation: | [1] Univ Sao Paulo, Sch Med, Heart Inst InCor, BR-05508030 Sao Paulo - Brazil
[2] Univ Fed Triangulo Mineiro, Sch Med, Uberaba, MG - Brazil
[3] Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508030 Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY; v. 113, n. 3, p. 671-679, MAR 2013. |
| Web of Science Citations: | 6 |
| Abstract | |
Previous investigations show that metabolic syndrome (MetSyn) causes sympathetic hyperactivation. Symptoms of anxiety and mood disturbance (AMd) provoke sympatho-vagal imbalance. We hypothesized that AMd would alter even further the autonomic function in patients with MetSyn. Twenty-six never-treated patients with MetSyn (ATP-III) were allocated to two groups, according to the levels of anxiety and mood disturbance: (1) with AMd (MetSyn + AMd, n = 15), and (2) without AMd (MetSyn, n = 11). Ten healthy control subjects were also studied (C, n = 10). AMd was determined using quantitative questionnaires. Muscle sympathetic nerve activity (MSNA, microneurography), blood pressure (oscillometric beat-to-beat basis), and heart rate (ECG) were measured during a baseline 10-min period. Spectral analysis of RR interval and systolic arterial pressure were analyzed, and the power of low (LF) and high (HF) frequency bands were determined. Sympatho-vagal balance was obtained by LF/HF ratio. Spontaneous baroreflex sensitivity (BRS) was evaluated by calculation of alpha-index. MSNA was greater in patients with MetSyn + AMd compared with MetSyn and C. Patients with MetSyn + AMd showed higher LF and lower HF power compared with MetSyn and C. In addition, LF/HF balance was higher in MetSyn + AMd than in MetSyn and C groups. BRS was decreased in MetSyn + AMd compared with MetSyn and C groups. Anxiety and mood disturbance alter autonomic function in patients with MetSyn. This autonomic dysfunction may contribute to the increased cardiovascular risk observed in patients with mood alterations. (AU) | |
| FAPESP's process: | 10/50048-1 - Cellular and functional bases of exercise in cardiovascular diseases |
| Grantee: | Carlos Eduardo Negrão |
| Support type: | Research Projects - Thematic Grants |
| FAPESP's process: | 08/03714-6 - 3D body scan to diagnose obesity and assess cardiovascular risk |
| Grantee: | Ivani Credidio Trombetta |
| Support type: | Scholarships abroad - New Frontiers |