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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Symptoms of anxiety and mood disturbance alter cardiac and peripheral autonomic control in patients with metabolic syndrome

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Author(s):
Toschi-Dias, Edgar [1] ; Trombetta, Ivani C. [1] ; Dias da Silva, Valdo Jose [2] ; Maki-Nunes, Cristiane [1] ; Alves, Maria Janieire N. N. [1] ; Angelo, Luciana F. [1] ; Cepeda, Felipe X. [1] ; Martinez, Daniel G. [1] ; Negrao, Carlos Eduardo [3, 1] ; Rondon, Maria Urbana P. B. [1, 3]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Sch Med, Heart Inst InCor, BR-05508030 Sao Paulo - Brazil
[2] Univ Fed Triangulo Mineiro, Sch Med, Uberaba, MG - Brazil
[3] Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508030 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY; v. 113, n. 3, p. 671-679, MAR 2013.
Web of Science Citations: 6
Abstract

Previous investigations show that metabolic syndrome (MetSyn) causes sympathetic hyperactivation. Symptoms of anxiety and mood disturbance (AMd) provoke sympatho-vagal imbalance. We hypothesized that AMd would alter even further the autonomic function in patients with MetSyn. Twenty-six never-treated patients with MetSyn (ATP-III) were allocated to two groups, according to the levels of anxiety and mood disturbance: (1) with AMd (MetSyn + AMd, n = 15), and (2) without AMd (MetSyn, n = 11). Ten healthy control subjects were also studied (C, n = 10). AMd was determined using quantitative questionnaires. Muscle sympathetic nerve activity (MSNA, microneurography), blood pressure (oscillometric beat-to-beat basis), and heart rate (ECG) were measured during a baseline 10-min period. Spectral analysis of RR interval and systolic arterial pressure were analyzed, and the power of low (LF) and high (HF) frequency bands were determined. Sympatho-vagal balance was obtained by LF/HF ratio. Spontaneous baroreflex sensitivity (BRS) was evaluated by calculation of alpha-index. MSNA was greater in patients with MetSyn + AMd compared with MetSyn and C. Patients with MetSyn + AMd showed higher LF and lower HF power compared with MetSyn and C. In addition, LF/HF balance was higher in MetSyn + AMd than in MetSyn and C groups. BRS was decreased in MetSyn + AMd compared with MetSyn and C groups. Anxiety and mood disturbance alter autonomic function in patients with MetSyn. This autonomic dysfunction may contribute to the increased cardiovascular risk observed in patients with mood alterations. (AU)

FAPESP's process: 10/50048-1 - Cellular and functional bases of exercise in cardiovascular diseases
Grantee:Carlos Eduardo Negrão
Support type: Research Projects - Thematic Grants
FAPESP's process: 08/03714-6 - 3D body scan to diagnose obesity and assess cardiovascular risk
Grantee:Ivani Credidio Trombetta
Support type: Scholarships abroad - New Frontiers