Effect of physical training in functional capacity, metabolic profile, body composition and quality of life in patients with congenital heart disease

• Grant number: 19/26076-0
• Support type: Regular Research Grants
• Duration: July 01, 2021 - June 30, 2023
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal researcher: Marcelo Biscegli Jatene
• Grantee: Marcelo Biscegli Jatene
• Home Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Assoc. researchers: Aída Luiza Ribeiro Turquetto ; Carlos Eduardo Negrão ; Daniela Regina Agostinho ; Luciana Patrick Amato ; Luiz Fernando Canêo ; Nana Miura Ikari ; Patricia Alves de Oliveira

Abstract

Introduction: Patients with congenital heart disease (CHD) show exercise intolerance, most of the time caused by physical inactivity, since children were not stimulated to be physically active. Currently adolescents and young adults are developing overweight, obesity and metabolic syndrome, it is believed that, one of the causes, is the sedentary lifestyle. The number of patients who are developing these risk factors for the development of heart disease, such as atherosclerosis, already resembles the number of patients who do not have CHD, leading to a concern, generating a public health problem. Objective: To test the hypothesis that unsupervised physical training improves physical capacity, body composition, quality of life, metabolic markers in patients with CHD. Moreover, this exercise-based paradigm will improve neurovascular control and vagal and sympathetic modulation of the heart in this group of patients. Methods: Clinical randomized controlled trial. 40 patients with any CC, over 14 years of age will be studied. All will be previously evaluated and randomized into two groups: GTF: group that will perform physical training and CG: control group that will not perform physical training. The GTF will perform 3 months of physical exercises accompanied by distance, through exercise spreadsheet, phone calls and text messages, and a visit each month to check the progress of training. These patients will be reevaluated after 3 months. Individuals from the CG will receive guidance to maintain their activities of daily living and after three months will be reevaluated. At the end of the study, they will be instructed regarding the practice of physical exercises.Expected Results: It is expected to identify increased functional capacity, improved quality of life and metabolic markers after the period of physical training. It is also expected to identify the possible components that act on the neurovascular and metabolic impairment of patients with CHD that may lead to the development of risk factors for cardiovascular diseases and decrease functional capacity.Keywords: Congenital heart diseases, cardiovascular surgery, exercise, cardiopulmonary exercise test, biomarkers, quality of life. (AU)