New therapeutics to modulate mitochondrial dynamics and mitophagy in cardiac diseases

Autor(es)

Disatnik, Marie-Helene ^[1] ; Hwang, Sunhee ^[1] ; Ferreira, Julio C. B. ^[2] ; Mochly-Rosen, Daria ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] Stanford Univ, Sch Med, Dept Chem & Syst Biol, Stanford, CA 94305 - USA

^[2] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, BR-05508000 Sao Paulo - Brazil

^[3] Stanford Univ, Sch Med, Dept Chem & Syst Biol, CCSR, Stanford, CA 94305 - USA

• Tipo de documento: Artigo de Revisão
• Fonte: JOURNAL OF MOLECULAR MEDICINE-JMM; v. 93, n. 3, p. 279-287, MAR 2015.
• Citações Web of Science: 9

Resumo

The processes that control the number and shape of the mitochondria (mitochondrial dynamics) and the removal of damaged mitochondria (mitophagy) have been the subject of intense research. Recent work indicates that these processes may contribute to the pathology associated with cardiac diseases. This review describes some of the key proteins that regulate these processes and their potential as therapeutic targets for cardiac diseases. (AU)

• Processo FAPESP: 12/05765-2 - Contribuição da enzima aldeído desidrogenase 2 na progressão da insuficiência cardíaca
• Beneficiário: Julio Cesar Batista Ferreira
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores