New therapeutics to modulate mitochondrial dynamics and mitophagy in cardiac diseases

Disatnik, Marie-Helene; Hwang, Sunhee; Ferreira, Julio C. B.; Mochly-Rosen, Daria

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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

New therapeutics to modulate mitochondrial dynamics and mitophagy in cardiac diseases

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Author(s):	Disatnik, Marie-Helene ^[1] ; Hwang, Sunhee ^[1] ; Ferreira, Julio C. B. ^[2] ; Mochly-Rosen, Daria ^{[1, 3]} Total Authors: 4
Affiliation:	^[1] Stanford Univ, Sch Med, Dept Chem & Syst Biol, Stanford, CA 94305 - USA ^[2] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, BR-05508000 Sao Paulo - Brazil ^[3] Stanford Univ, Sch Med, Dept Chem & Syst Biol, CCSR, Stanford, CA 94305 - USA Total Affiliations: 3
Document type:	Review article
Source:	JOURNAL OF MOLECULAR MEDICINE-JMM; v. 93, n. 3, p. 279-287, MAR 2015.
Web of Science Citations:	9
Abstract
The processes that control the number and shape of the mitochondria (mitochondrial dynamics) and the removal of damaged mitochondria (mitophagy) have been the subject of intense research. Recent work indicates that these processes may contribute to the pathology associated with cardiac diseases. This review describes some of the key proteins that regulate these processes and their potential as therapeutic targets for cardiac diseases. (AU)

FAPESP's process:	12/05765-2 - Contribution of aldehyde dehydrogenase 2 to heart failure development
Grantee:	Julio Cesar Batista Ferreira
Support Opportunities:	Research Grants - Young Investigators Grants

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