The effects of Cyclosporin A and Heteropterys tomentosa on the rat liver

Autor(es)

de Freitas, Karine M. ^[1] ; Almeida, Jacqueline M. ^[1] ; Monteiro, Juliana C. ^[2] ; Diamante, Maria Aparecida S. ^[1] ; do Vale, Jessica S. F. ^[1] ; Camargo, Camila ^[3] ; Jorge, Marcal H. A. ^[4] ; Dolder, Heidi ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Dept Biol Estrutural & Func, BR-13083865 Campinas, SP - Brazil

^[2] Univ Fed Espirito Santo, Dept Ciencias Agron & Biol, BR-29932540 Sao Mateus, ES - Brazil

^[3] Univ Estadual Campinas, Dept Bioquim, BR-13083970 Campinas, SP - Brazil

^[4] Empresa Brasileira Pesquisa Agr Embrapa Hortal, Tecnol Mudas & Sementes, BR-70351970 Gama, DF - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Anais da Academia Brasileira de Ciências; v. 87, n. 1, p. 369-379, MAR 2015.
• Citações Web of Science: 4

Resumo

Cyclosporin A (CsA) is a widely employed immunosuppressive drug that is associated with several side effects, among then hepatotoxicity. Heteropterys tomentosa is a Brazilian plant efficient in reducing damage caused by CsA on the rat testis and prostate. The aim of this study was to evaluate the effect of CsA and H. tomentosa (administered isolated or simultaneously) on the liver of Wistar rats. The animals were treated daily with water (control), CsA (15mg/kg/day), H. tomentosa infusion or CsA+H. tomentosa, for 21 or 56 days. The treatments did not alter liver morphology or cause fibrosis. H. tomentosa administered for 21 days increased the number of hepatocyte nuclei and Kupffer cell volumetric proportion. After 56 days of treatment, H. tomentosa administration did not alter the parameters analyzed. Biochemical plasma dosages and liver stereology showed impairment caused by CsA-treatment after 21 days; these results were not observed after 56 days of treatment. The simultaneous treatment with CsA and H. tomentosa for 21 or 56 days did not alleviate nor accentuate CsA hepatic effects. The present study showed that the 21 days treatment with CsA caused more alteration to the liver than the 56 days treatment; this could be related to hepatic recovery after the long term treatment. (AU)

• Processo FAPESP: 11/01160-6 - A infusão de nó-de-cachorro (Heteropterys aphrodisiaca, O. Mach, 1949) ameniza os efeitos colaterais da Ciclosporina A ou altera a sua atividade imunossupressora em ratos Wistar?
• Beneficiário: Karine Moura de Freitas
• Modalidade de apoio: Bolsas no Brasil - Doutorado