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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The effects of Cyclosporin A and Heteropterys tomentosa on the rat liver

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Author(s):
de Freitas, Karine M. [1] ; Almeida, Jacqueline M. [1] ; Monteiro, Juliana C. [2] ; Diamante, Maria Aparecida S. [1] ; do Vale, Jessica S. F. [1] ; Camargo, Camila [3] ; Jorge, Marcal H. A. [4] ; Dolder, Heidi [1]
Total Authors: 8
Affiliation:
[1] Univ Estadual Campinas, Dept Biol Estrutural & Func, BR-13083865 Campinas, SP - Brazil
[2] Univ Fed Espirito Santo, Dept Ciencias Agron & Biol, BR-29932540 Sao Mateus, ES - Brazil
[3] Univ Estadual Campinas, Dept Bioquim, BR-13083970 Campinas, SP - Brazil
[4] Empresa Brasileira Pesquisa Agr Embrapa Hortal, Tecnol Mudas & Sementes, BR-70351970 Gama, DF - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Anais da Academia Brasileira de Ciências; v. 87, n. 1, p. 369-379, MAR 2015.
Web of Science Citations: 4
Abstract

Cyclosporin A (CsA) is a widely employed immunosuppressive drug that is associated with several side effects, among then hepatotoxicity. Heteropterys tomentosa is a Brazilian plant efficient in reducing damage caused by CsA on the rat testis and prostate. The aim of this study was to evaluate the effect of CsA and H. tomentosa (administered isolated or simultaneously) on the liver of Wistar rats. The animals were treated daily with water (control), CsA (15mg/kg/day), H. tomentosa infusion or CsA+H. tomentosa, for 21 or 56 days. The treatments did not alter liver morphology or cause fibrosis. H. tomentosa administered for 21 days increased the number of hepatocyte nuclei and Kupffer cell volumetric proportion. After 56 days of treatment, H. tomentosa administration did not alter the parameters analyzed. Biochemical plasma dosages and liver stereology showed impairment caused by CsA-treatment after 21 days; these results were not observed after 56 days of treatment. The simultaneous treatment with CsA and H. tomentosa for 21 or 56 days did not alleviate nor accentuate CsA hepatic effects. The present study showed that the 21 days treatment with CsA caused more alteration to the liver than the 56 days treatment; this could be related to hepatic recovery after the long term treatment. (AU)

FAPESP's process: 11/01160-6 - Does the "nó-de-cachorro" (Heteropterys aphrodisiaca, O. Mach, 1949) infusion relieves the CsA collateral effects or amendts its imunossupressive activity in Wistar rats?
Grantee:Karine Moura de Freitas
Support Opportunities: Scholarships in Brazil - Doctorate