Are podoplanin and ezrin involved in the invasion process of the ameloblastomas?

Autor(es)

Costa, Y. F. ^[1] ; Tjioe, K. C. ^[1] ; Nonogaki, S. ^[2] ; Soares, F. A. ^[3] ; Lauris, J. R. Pereira ^[1] ; Oliveira, D. Tostes ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Bauru Sch Dent, Dept Stomatol, Area Pathol, BR-17012901 Bauru, SP - Brazil

^[2] Adolfo Lutz Inst, Div Pathol, Sao Paulo - Brazil

^[3] AC Camargo Canc Hosp, Dept Pathol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: EUROPEAN JOURNAL OF HISTOCHEMISTRY; v. 59, n. 1, p. 39-44, 2015.
• Citações Web of Science: 8

Resumo

The association between podoplanin and ezrin in the process of odontogenic tumors invasion has been suggested, but was not studied yet. Our purpose was to investigate the relationship between podoplanin and ezrin expressions in the odontogenic epithelium of ameloblastomas. Forty-seven ameloblastomas were analyzed by immunohistochemistry using anti-podoplanin and anti-ezrin antibodies. The expressions of both proteins were evaluated using a score method and the comparison and association between these proteins were verified, respectively, by Wilcoxon Signed-Rank test and by Spearman's rank correlation coefficient, using a statistical significance level of 0.05. The majority of tumors (87.2%) exhibited strong membranous expression of podoplanin in the peripheral cells. Cytoplasmic expression of ezrin in the peripheral cells of ameloblastomas was stronger than its membranous expression. No statistically significant correlation was observed between podoplanin and ezrin. However, there was statistically significant difference between membranous podoplanin and membranous ezrin expressions, between cytoplasmic podoplanin and membranous ezrin expressions, and between cytoplasmic podoplanin and cytoplasmic ezrin expressions. There was no statistical difference between membranous podoplanin and cytoplasmic ezrin expressions. These results suggest a synergistic role of both proteins in the process of invasion of ameloblastomas. (AU)

• Processo FAPESP: 12/08278-5 - A podoplanina está associada à ezrin no processo de invasão dos ameloblastomas?
• Beneficiário: Yara Francine Costa
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 12/13411-6 - Participação da podoplanina no processo de remodelação celular em tumores odontogênicos benignos e tumores epiteliais malignos de boca
• Beneficiário: Denise Tostes Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular