| Full text | |
| Author(s): |
Costa, Y. F.
[1]
;
Tjioe, K. C.
[1]
;
Nonogaki, S.
[2]
;
Soares, F. A.
[3]
;
Lauris, J. R. Pereira
[1]
;
Oliveira, D. Tostes
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Sao Paulo, Bauru Sch Dent, Dept Stomatol, Area Pathol, BR-17012901 Bauru, SP - Brazil
[2] Adolfo Lutz Inst, Div Pathol, Sao Paulo - Brazil
[3] AC Camargo Canc Hosp, Dept Pathol, Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | EUROPEAN JOURNAL OF HISTOCHEMISTRY; v. 59, n. 1, p. 39-44, 2015. |
| Web of Science Citations: | 8 |
| Abstract | |
The association between podoplanin and ezrin in the process of odontogenic tumors invasion has been suggested, but was not studied yet. Our purpose was to investigate the relationship between podoplanin and ezrin expressions in the odontogenic epithelium of ameloblastomas. Forty-seven ameloblastomas were analyzed by immunohistochemistry using anti-podoplanin and anti-ezrin antibodies. The expressions of both proteins were evaluated using a score method and the comparison and association between these proteins were verified, respectively, by Wilcoxon Signed-Rank test and by Spearman's rank correlation coefficient, using a statistical significance level of 0.05. The majority of tumors (87.2%) exhibited strong membranous expression of podoplanin in the peripheral cells. Cytoplasmic expression of ezrin in the peripheral cells of ameloblastomas was stronger than its membranous expression. No statistically significant correlation was observed between podoplanin and ezrin. However, there was statistically significant difference between membranous podoplanin and membranous ezrin expressions, between cytoplasmic podoplanin and membranous ezrin expressions, and between cytoplasmic podoplanin and cytoplasmic ezrin expressions. There was no statistical difference between membranous podoplanin and cytoplasmic ezrin expressions. These results suggest a synergistic role of both proteins in the process of invasion of ameloblastomas. (AU) | |
| FAPESP's process: | 12/08278-5 - Is the podoplanin associated to ezrin in process of invasion of ameloblastomas? |
| Grantee: | Yara Francine Costa |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 12/13411-6 - The role of podoplanin in the process of cellular remodelling in benign odontogenic tumors and oral malignant epithelial tumors |
| Grantee: | Denise Tostes Oliveira |
| Support Opportunities: | Regular Research Grants |