Serum interleukin-17 levels are associated with nephritis in childhood-onset systemic lupus erythematosus

Autor(es)

Pelicari, Karina de Oliveira ^[1] ; Postal, Mariana ^[1] ; Sinicato, Nailu Angelica ^[1] ; Peres, Fernando Augusto ^[1] ; Fernandes, Paula Teixeira ^[2] ; Marini, Roberto ^[3] ; Lavras Costallat, Lilian Tereza ^[4] ; Appenzeller, Simone ^{[4, 1]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, UNICAMP, Fac Med Sci, Rheumatol Lab, Campinas, SP - Brazil

^[2] Univ Estadual Campinas, UNICAMP, Fac Phys Educ, Dept Sport Sci, Campinas, SP - Brazil

^[3] Univ Estadual Campinas, UNICAMP, Fac Med Sci, Dept Pediat, Pediat Rheumatol Unit, Campinas, SP - Brazil

^[4] Univ Estadual Campinas, UNICAMP, Fac Med Sci, Dept Med, Rheumatol Unit, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Clinics; v. 70, n. 5, p. 313-317, 2015.
• Citações Web of Science: 8

Resumo

OBJECTIVES: To determine the serum interleukin-17 (IL-17) levels in childhood-onset systemic lupus erythematosus patients and to evaluate the association between IL-17 and clinical manifestations, disease activity, laboratory findings and treatment. METHODS: We included 67 consecutive childhood-onset systemic lupus erythematosus patients [61 women; median age 18 years (range 11-31)], 55 first-degree relatives [50 women; median age 40 years (range 29-52)] and 47 age- and sex-matched healthy controls [42 women; median age 19 years (range 6-30)]. The childhood-onset systemic lupus erythematosus patients were assessed for clinical and laboratory systemic lupus erythematosus manifestations, disease activity [Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)], cumulative damage [Systemic Lupus International Collaborating Clinics/American College of Rheumatology (ACR) Damage Index] and current drug use. Serum IL-17 levels were measured by an enzyme-linked immunosorbent assay using commercial kits. RESULTS: The median serum IL-17 level was 36.3 (range 17.36-105.92) pg/mL in childhood-onset systemic lupus erythematosus patients and 29.47 (15.16-62.17) pg/mL in healthy controls (p=0.009). We observed an association between serum IL-17 levels and active nephritis (p=0.01) and migraines (p=0.03). Serum IL-17 levels were not associated with disease activity (p=0.32), cumulative damage (p=0.34), or medication use (p=0.63). CONCLUSION: IL-17 is increased in childhood-onset systemic lupus erythematosus and may play a role in the pathogenesis of neuropsychiatric and renal manifestations. Longitudinal studies are necessary to determine the role of IL-17 in childhood-onset systemic lupus erythematosus. (AU)

• Processo FAPESP: 08/02917-0 - Determinação de marcadores séricos e do líquor associados a alterações estruturais e funcionais do sistema nervoso central no lúpus eritematoso sistêmico
• Beneficiário: Simone Appenzeller
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 12/21071-0 - Estudo longitudinal das interleucinas 6, 10, 12 e 17 e associações clínicas e laboratoriais em pacientes com lúpus eritematoso sistêmico
• Beneficiário: Karina de Oliveira Peliçari
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 10/13636-2 - Manifestações clínicas e laboratoriais associadas a IL - 17 no lúpus eritematoso sistêmico
• Beneficiário: Karina de Oliveira Peliçari
• Modalidade de apoio: Bolsas no Brasil - Mestrado