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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Assisted deposition of nano-hydroxyapatite onto exfoliated carbon nanotube oxide scaffolds

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Autor(es):
Zanin, H. [1, 2] ; Rosa, C. M. R. [1] ; Eliaz, N. [3] ; May, P. W. [4] ; Marciano, F. R. [1] ; Lobo, A. O. [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Vale Paraiba UniVap, Inst Res & Dev IP&D, Lab Biomed Nanotechnol, BR-12244000 Sao Jose Dos Campos, SP - Brazil
[2] IP&D Univap, Lab Energy Storage & Supply ES&S, Sao Paulo - Brazil
[3] Tel Aviv Univ, Dept Mat Sci & Engn, IL-6997801 Tel Aviv - Israel
[4] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon - England
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: NANOSCALE; v. 7, n. 22, p. 10218-10232, 2015.
Citações Web of Science: 34
Resumo

Electrodeposited nano-hydroxyapatite (nHAp) is more similar to biological apatite in terms of microstructure and dimension than apatites prepared by other processes. Reinforcement with carbon nanotubes (CNTs) enhances its mechanical properties and increases adhesion of osteoblasts. Here, we carefully studied nHAp deposited onto vertically aligned multi-walled CNT (VAMWCNT) scaffolds by electrodeposition and soaking in a simulated body fluid (SBF). VAMWCNTs are porous biocompatible scaffolds with nanometric porosity and exceptional mechanical and chemical properties. The VAMWCNT films were prepared on a Ti substrate by a microwave plasma chemical vapour deposition method, and then oxidized and exfoliated by oxygen plasma etching (OPE) to produce graphene oxide (GO) at the VAMWCNT tips. The attachment of oxygen functional groups was found to be crucial for nHAp nucleation during electrodeposition. A thin layer of plate-like and needle-like nHAp with high crystallinity was formed without any need for thermal treatment. This composite (henceforth referred to as nHAp-VAMWCNT-GO) served as the scaffold for in vitro biomineralization when soaked in the SBF, resulting in the formation of both carbonate-rich and carbonate-poor globular-like nHAp. Different steps in the deposition of biological apatite onto VAMWCNT-GO and during the short-term biomineralization process were analysed. Due to their unique structure and properties, such nano-bio-composites may become useful in accelerating in vivo bone regeneration processes. (AU)

Processo FAPESP: 11/20345-7 - Estudo de filmes de carbono-tipo diamante contendo nanopartículas incorporadas para aplicações biomédicas
Beneficiário:Fernanda Roberta Marciano
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores
Processo FAPESP: 11/17877-7 - Desenvolvimento de novos scaffolds poliméricos por eletrofiação com incorporação de nanotubos alinhados e nanohidroxiapatita para regeneração óssea
Beneficiário:Anderson de Oliveira Lobo
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores
Processo FAPESP: 14/02163-7 - Desenvolvimento de dispositivos supercapacitores a partir de grafenos, nanotubos de carbono e diamantes
Beneficiário:Hudson Giovani Zanin
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores