Electrochemical determination of rosuvastatin calcium in pharmaceutical and human body fluid samples using a composite of vertically aligned carbon nanotubes and graphene oxide as the electrode material

Autor(es)

Silva, Tiago Almeida ^[1] ; Zanin, Hudson ^[2] ; Vicentini, Fernando Campanha ^[1] ; Corat, Evaldo Jose ^[3] ; Fatibello-Filho, Orlando ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Dept Chem, BR-13560970 Sao Carlos, SP - Brazil

^[2] Univap, Inst Res & Dev IP&D, Lab Energy Storage & Supply ES&S, BR-12224000 Sao Jose Dos Campos, SP - Brazil

^[3] Natl Inst Space Res, BR-12227010 Sao Jose Dos Campos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SENSORS AND ACTUATORS B-CHEMICAL; v. 218, p. 51-59, OCT 31 2015.
• Citações Web of Science: 19

Resumo

A novel electrochemical method for the determination of rosuvastatin calcium (RC) using a composite of vertically aligned carbon nanotubes and graphene oxide (VACNT-GO) as the electrode material is proposed. The VACNT-GO electrode was synthesized using a microwave-assisted chemical vapor deposition method followed by oxygen plasma treatment. The VACNT-GO electrode presented super-hydrophilic behavior and fast charge transfer, which are very attractive for electrochemical applications. The RC molecule presented an oxidation process at +1.26 V vs. Ag/AgCl (3.0 mol L-1 KCl) in phosphate buffer solution (pH 2), and this redox behavior was explored for its voltammetric determination. Using square-wave adsorptive anodic stripping voltammetry (SWAdASV) under optimized conditions, the analytical curve was linear in RC concentration range from 0.48 to 46.72 mu mol L-1 with a limit of detection of 0.06 mu mol L-1. The developed SWAdASV method was applied for RC quantification in commercial pharmaceutical samples, and the results are consistent with those obtained by the comparative spectrophotometric method at a confidence level of 95%. Moreover, RC was determined in human body fluid samples of urine and human serum. (C) 2015 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 14/02163-7 - Desenvolvimento de dispositivos supercapacitores a partir de grafenos, nanotubos de carbono e diamantes
• Beneficiário: Hudson Giovani Zanin
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 14/21587-2 - Desenvolvimento de dispositivos supercapacitores a partir de grafenos, nanotubos de carbono e diamantes
• Beneficiário: Hudson Giovani Zanin
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores
• Processo FAPESP: 13/16770-0 - Desenvolvimento de sensores à base de filmes poliméricos e nanomateriais para aplicações analíticas diversas
• Beneficiário: Fernando Campanhã Vicentini
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado