| Full text | |
| Author(s): |
Silva, Tiago Almeida
[1]
;
Zanin, Hudson
[2]
;
Vicentini, Fernando Campanha
[1]
;
Corat, Evaldo Jose
[3]
;
Fatibello-Filho, Orlando
[1]
Total Authors: 5
|
| Affiliation: | [1] Univ Fed Sao Carlos, Dept Chem, BR-13560970 Sao Carlos, SP - Brazil
[2] Univap, Inst Res & Dev IP&D, Lab Energy Storage & Supply ES&S, BR-12224000 Sao Jose Dos Campos, SP - Brazil
[3] Natl Inst Space Res, BR-12227010 Sao Jose Dos Campos, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | SENSORS AND ACTUATORS B-CHEMICAL; v. 218, p. 51-59, OCT 31 2015. |
| Web of Science Citations: | 19 |
| Abstract | |
A novel electrochemical method for the determination of rosuvastatin calcium (RC) using a composite of vertically aligned carbon nanotubes and graphene oxide (VACNT-GO) as the electrode material is proposed. The VACNT-GO electrode was synthesized using a microwave-assisted chemical vapor deposition method followed by oxygen plasma treatment. The VACNT-GO electrode presented super-hydrophilic behavior and fast charge transfer, which are very attractive for electrochemical applications. The RC molecule presented an oxidation process at +1.26 V vs. Ag/AgCl (3.0 mol L-1 KCl) in phosphate buffer solution (pH 2), and this redox behavior was explored for its voltammetric determination. Using square-wave adsorptive anodic stripping voltammetry (SWAdASV) under optimized conditions, the analytical curve was linear in RC concentration range from 0.48 to 46.72 mu mol L-1 with a limit of detection of 0.06 mu mol L-1. The developed SWAdASV method was applied for RC quantification in commercial pharmaceutical samples, and the results are consistent with those obtained by the comparative spectrophotometric method at a confidence level of 95%. Moreover, RC was determined in human body fluid samples of urine and human serum. (C) 2015 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 14/02163-7 - Development of supercapacitors devices from graphene, carbon nanotubes and diamonds |
| Grantee: | Hudson Giovani Zanin |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 14/21587-2 - Development of supercapacitors devices from graphene, carbon nanotubes and diamonds |
| Grantee: | Hudson Giovani Zanin |
| Support Opportunities: | Scholarships in Brazil - Young Researchers |
| FAPESP's process: | 13/16770-0 - SENSORS DEVELOPMENT BASED ON POLYMERIC FILMS AND NANOMATERIALS FOR SEVERAL ANALYTICAL APPLICATIONS |
| Grantee: | Fernando Campanhã Vicentini |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |