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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Electrochemical determination of rosuvastatin calcium in pharmaceutical and human body fluid samples using a composite of vertically aligned carbon nanotubes and graphene oxide as the electrode material

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Author(s):
Silva, Tiago Almeida [1] ; Zanin, Hudson [2] ; Vicentini, Fernando Campanha [1] ; Corat, Evaldo Jose [3] ; Fatibello-Filho, Orlando [1]
Total Authors: 5
Affiliation:
[1] Univ Fed Sao Carlos, Dept Chem, BR-13560970 Sao Carlos, SP - Brazil
[2] Univap, Inst Res & Dev IP&D, Lab Energy Storage & Supply ES&S, BR-12224000 Sao Jose Dos Campos, SP - Brazil
[3] Natl Inst Space Res, BR-12227010 Sao Jose Dos Campos, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: SENSORS AND ACTUATORS B-CHEMICAL; v. 218, p. 51-59, OCT 31 2015.
Web of Science Citations: 19
Abstract

A novel electrochemical method for the determination of rosuvastatin calcium (RC) using a composite of vertically aligned carbon nanotubes and graphene oxide (VACNT-GO) as the electrode material is proposed. The VACNT-GO electrode was synthesized using a microwave-assisted chemical vapor deposition method followed by oxygen plasma treatment. The VACNT-GO electrode presented super-hydrophilic behavior and fast charge transfer, which are very attractive for electrochemical applications. The RC molecule presented an oxidation process at +1.26 V vs. Ag/AgCl (3.0 mol L-1 KCl) in phosphate buffer solution (pH 2), and this redox behavior was explored for its voltammetric determination. Using square-wave adsorptive anodic stripping voltammetry (SWAdASV) under optimized conditions, the analytical curve was linear in RC concentration range from 0.48 to 46.72 mu mol L-1 with a limit of detection of 0.06 mu mol L-1. The developed SWAdASV method was applied for RC quantification in commercial pharmaceutical samples, and the results are consistent with those obtained by the comparative spectrophotometric method at a confidence level of 95%. Moreover, RC was determined in human body fluid samples of urine and human serum. (C) 2015 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 13/16770-0 - Sensors development based on polymeric films and nanomaterials for several analytical applications
Grantee:Fernando Campanhã Vicentini
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 14/02163-7 - Development of supercapacitors devices from graphene, carbon nanotubes and diamonds
Grantee:Hudson Giovani Zanin
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 14/21587-2 - Development of supercapacitors devices from graphene, carbon nanotubes and diamonds
Grantee:Hudson Giovani Zanin
Support type: Scholarships in Brazil - Young Researchers