Molecular events in relapsed oral squamous cell carcinoma: Recurrence vs secondary primary tumor

Autor(es):Mostrar menos -

Gleber-Netto, Frederico O. ^[1] ; Braakhuis, Boudewijn J. M. ^[2] ; Triantafyllou, Asterios ^{[3, 4]} ; Takes, Robert P. ^[5] ; Kelner, Natalie ^[6] ; Rodrigo, Juan P. ^{[7, 8]} ; Strojan, Primoz ^[9] ; Vander Poorten, Vincent ^[10] ; Rapidis, Alexander D. ^[11] ; Rinaldo, Alessandra ^[12] ; Brakenhoff, Ruud H. ^[2] ; Ferlito, Alfio ^[13] ; Kowalski, Luiz P. ^{[14, 6]}

Afiliação do(s) autor(es):Mostrar menos -

^[1] AC Camargo Canc Ctr, Int Res Ctr, Lab Med Genom, Sao Paulo - Brazil

^[2] Vrije Univ Amsterdam Med Ctr, Dept Otolaryngol Head & Neck Surg, Amsterdam - Netherlands

^[3] Univ Liverpool, Sch Dent, Oral & Maxillofacial Pathol, Liverpool L69 3BX, Merseyside - England

^[4] Aintree Univ Hosp NHS Fdn Trust, Cellular Pathol, Liverpool L9 7AL, Merseyside - England

^[5] Radboud Univ Nijmegen, Med Ctr, Dept Otolaryngol Head & Neck Surg, NL-6525 ED Nijmegen - Netherlands

^[6] AC Camargo Canc Ctr, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo - Brazil

^[7] Univ Oviedo, Hosp Univ Cent Asturias, Dept Otolaryngol, Oviedo - Spain

^[8] Inst Univ Oncol Principado Asturias, Oviedo - Spain

^[9] Inst Oncol, Dept Radiat Oncol, Ljubljana - Slovenia

^[10] Univ Hosp KU Leuven, Dept Oncol Sect Head & Neck Oncol, Otorhinolaryngol Head & Neck Surg, Leuven - Belgium

^[11] St Savvas Hosp, Greek Anticanc Inst, Dept Head & Neck Surg, Athens - Greece

^[12] Univ Udine, Sch Med, I-33100 Udine - Italy

^[13] AC Camargo Canc Ctr, Int Head & Neck Sci Grp, Sao Paulo - Brazil

^[14] Natl Inst Sci & Technol Oncogen INCITO, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Oral Oncology; v. 51, n. 8, p. 738-744, AUG 2015.
• Citações Web of Science: 14

Resumo

Relapses have a great impact on both the morbidity and mortality rates of oral squamous cell carcinoma (OSCC) patients. Current classification criteria are imprecise and need improvements. Recent advances in understanding of OSCC relapses on a molecular level provide new possibilities to better classify true recurrences and second primary tumors. This review discusses the limitations of the current OSCC relapse classification method and presents possible alternatives to improve this classification based on molecular techniques. Moreover, these molecular techniques add to the further understanding of these lesions and may provide tools for clinical management. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 11/13315-4 - Estudo em larga-escala de alterações transcricionais relacionadas à ocorrência de metástases no câncer oral.
• Beneficiário: Frederico Omar Gleber Netto
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 13/09142-2 - Estudo de marcadores salivares relacionados à metástase nodal em carcinoma epidermóide de boca
• Beneficiário: Frederico Omar Gleber Netto
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado