Human sporotrichosis beyond the epidemic front reveals classical transmission types in Espirito Santo, Brazil

Autor(es)

de Araujo, Mariceli L. ^[1] ; Rodrigues, Anderson M. ^[2] ; Fernandes, Geisa F. ^[2] ; de Camargo, Zoilo P. ^[2] ; de Hoog, G. Sybren ^[3]

Afiliação do(s) autor(es)

^[1] Fed Univ Espirito Santo UFES, Dept Pathol, Vitoria - Brazil

^[2] Fed Univ Sao Paulo UNIFESP, Dept Microbiol Immunol & Parasitol, Div Cell Biol, Sao Paulo - Brazil

^[3] KNAW Fungal Biodivers Ctr, Cent Bur Schimmelcultures, Utrecht - Netherlands

• Tipo de documento: Artigo Científico
• Fonte: MYCOSES; v. 58, n. 8, p. 485-490, AUG 2015.
• Citações Web of Science: 6

Resumo

Sporotrichosis has emerged as the main subcutaneous mycosis of humans and animals around the world. With particular differences in frequency, the major species includes Sporothrix brasiliensis, S.schenckii, S.globosa and S.luriei. In Brazil, the main aspect of this epidemic is based on the zoonotic transmission through the scratches and bites of diseased cats contaminated with S.brasiliensis. Areas free of feline sporotrichosis are poorly characterised in Brazil. We investigated by molecular tools the epidemiology of human sporotrichosis in the Espirito Santo (ES) state, an area adjacent to Rio de Janeiro where is the epicentre of the long-lasting outbreak of cat-transmitted sporotrichosis. The human cases in the ES state reveal the prevalence of classical transmission types where subjects are mainly infected by accidental traumatic inoculation during manipulation of contaminated plant material. In agreement with an environmental source, Sporothrix schenckii was the major aetiological agent in the classical transmission. Unlike Rio de Janeiro, this study shows that cat-transmitted epidemic in Espirito Santo is still scanty, although the geographic proximity and similar climatic features. Sporothrix brasiliensis was the agent in the feline-transmitted cases. Sporothrix globosa was isolated from a patient with fixed cutaneous lesions that did not report any contact with diseased animals. In conclusion, beyond the borders of Rio de Janeiro epidemic, agents of sporotrichosis in Espirito Santo show a scattered occurrence with high species diversity. (AU)

• Processo FAPESP: 11/07350-1 - Biologia do complexo Sporothrix schenckii: Análise de marcadores moleculares e proteômicos e o papel de moléculas antigênicas e antifúngicas na esporotricose
• Beneficiário: Anderson Messias Rodrigues
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 09/54024-2 - Biologia molecular e proteômica de fungos de interesse médico: Paracoccidioides brasiliensis e Sporothrix schenckii
• Beneficiário: Zoilo Pires de Camargo
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 11/01628-8 - Análise proteômica de isolados de Sporothrix schenckii diferentes entre si quanto à virulência através da técnica de iTRAQ/2-D LC-MS/MS
• Beneficiário: Geisa Ferreira Fernandes Sovegni
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado