A novel role for lncRNAs in cell cycle control during stress adaptation

Autor(es)

Sole, Carme ^[1] ; Nadal-Ribelles, Mariona ^[1] ; de Nadal, Eulalia ^[1] ; Posas, Francesc ^[1]

Afiliação do(s) autor(es)

^[1] Univ Pompeu Fabra, Dept Ciencies Expt & Salut, Cell Signaling Res Grp, Cell Signaling Unit, E-08003 Barcelona - Spain

• Tipo de documento: Artigo Científico
• Fonte: CURRENT GENETICS; v. 61, n. 3, p. 299-308, AUG 2015.
• Citações Web of Science: 19

Resumo

Eukaryotic cells have developed sophisticated systems to constantly monitor changes in the extracellular environment and to orchestrate a proper cellular response. To maximize survival, cells delay cell-cycle progression in response to environmental changes. In response to extracellular insults, stress-activated protein kinases (SAPKs) modulate cell-cycle progression and gene expression. In yeast, osmostress induces activation of the p38-related SAPK Hog1, which plays a key role in reprogramming gene expression upon osmostress. Genomic analysis has revealed the existence of a large number of long non-coding RNAs (lncRNAs) with different functions in a variety of organisms, including yeast. Upon osmostress, hundreds of lncRNAs are induced by the SAPK p38/Hog1. One gene that expresses Hog1-dependent lncRNA in an antisense orientation is the CDC28 gene, which encodes CDK1 kinase that controls the cell cycle in yeast. Cdc28 lncRNA mediates the induction of CDC28 expression and this increase in the level of Cdc28 results in more efficient re-entry of the cells into the cell cycle after stress. Thus, the control of lncRNA expression as a new mechanism for the regulation of cell-cycle progression opens new avenues to understand how stress adaptation can be accomplished in response to changing environments. (AU)

• Processo FAPESP: 14/01229-4 - International Symposium on Fungal Stress - ISFUS
• Beneficiário: Drauzio Eduardo Naretto Rangel
• Modalidade de apoio: Auxílio Organização - Reunião Científica