Cranial radiotherapy predisposes to abdominal adiposity in survivors of childhood acute lymphocytic leukemia

Autor(es)

Siviero-Miachon, Adriana Aparecida ^[1] ; Spinola-Castro, Angela Maria ^[1] ; de Martino Lee, Maria Lucia ^[2] ; Andreoni, Solange ^[3] ; Geloneze, Bruno ^[4] ; Lederman, Henrique ^[5] ; Guerra-Junior, Gil ^[6]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Div Pediat Endocrinol, Dept Pediat, UNIFESP EPM, Sao Paulo - Brazil

^[2] IOP GRAACC, Pediat Oncol Inst, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Dept Prevent & Social Med, Div Biostat, UNIFESP EPM, Sao Paulo - Brazil

^[4] Univ Estadual Campinas, Lab Invest Metab & Diabet LIMED, Fac Med Sci, UNICAMP, Campinas, SP - Brazil

^[5] Univ Fed Sao Paulo, Dept Diagnost Imaging, UNIFESP EPM, Sao Paulo - Brazil

^[6] Univ Estadual Campinas, Dept Pediat, Div Pediat Endocrinol, Fac Med Sci, UNICAMP, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: RADIATION ONCOLOGY; v. 8, FEB 21 2013.
• Citações Web of Science: 9

Resumo

Background: Advances in treatment of acute lymphocytic leukemia increased the likelihood of developing late treatment-associated effects, such as abdominal adiposity, increasing the risk of cardiovascular disease in this population. Cranial radiotherapy is one of the factors that might be involved in this process. The aim of this study was to determine the effect of cranial radiotherapy on adiposity indexes in survivors of acute lymphocytic leukemia. Methods: A comparative cross-sectional study of 56 acute lymphocytic leukemia survivors, chronological age between 15 and 24 years, assigned into two groups according to the exposure to cranial radiotherapy (25 irradiated and 31 non-irradiated), assessed according to body fat (dual energy X-ray absorptiometry), computed tomography scan-derived abdominal adipose tissue, lipid profile, and insulin resistance. Results: Cranial radiotherapy increased body fat and abdominal adipose tissue and altered lipid panel. Yet, lipids showed no clinical relevance so far. There were significantly more obese patients among those who received cranial radiotherapy (52% irradiated versus 22.6% non-irradiated), based on dual energy X-ray absorptiometry body fat measurements. Nonetheless, no association was observed between cranial radiotherapy and body mass index, waist circumference, waist-to-height ratio or insulin resistance. Conclusions: Adolescent and young adult survivors of childhood acute lymphocytic leukemia showed an increase in body fat and an alteration of fat distribution, which were related to cranial radiotherapy. Fat compartment modifications possibly indicate a disease of adipose tissue, and cranial radiotherapy imports in this process. (AU)

• Processo FAPESP: 06/06162-9 - Risco cardiovascular em adolescentes e adultos jovens tratados por leucemia linfocítica
• Beneficiário: Gil Guerra Júnior
• Modalidade de apoio: Auxílio à Pesquisa - Regular