Flavonoids and Methoxy-galloyiquinic Acid Derivatives from the Leaf Extract of Copaifera langsdorffii Desf.

Autor(es)

Nogueira, Mauro S. ^{[1, 2]} ; Furtado, Ricardo A. ^[1] ; Bastos, Jairo K. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Pharmaceut Sci, BR-14040903 Ribeirao Preto, SP - Brazil

^[2] Univ Munster, IPBP, D-48159 Munster - Germany

• Tipo de documento: Artigo Científico
• Fonte: Journal of Agricultural and Food Chemistry; v. 63, n. 31, p. 6939-6945, AUG 12 2015.
• Citações Web of Science: 11

Resumo

Despite reports on the pharmacological potential of Copaifera langsdorffii Desf. (Leguminosae-Caesalpinioideae) leaf extract, little is known about its chemical composition. In this work, a phytochemical study from the C. langsdoiffii ethanol/H2O 7:3 (v/v) extract was undertaken. Separation was performed by high-speed counter-current (HSCCC) and Sephadex LH-20 column chromatographies, followed by preparative HPLC. The EtOAc- and H2O-soluble fractions of the extract furnished the flavonoids quercitrin (1) and afzelin (2) and 3-O-(3-O-methyl-galloyOquinic acid (3), respectively. The H2O-soluble fraction furnished 3,4-di-O-(3-O-methyl-galloyOquinic acid (4), 3,5-di-O-(galloyl)-4-O-(3-O-methyl-galloyOquinic acid (5), and 3,5-di-O-(3-O-methyl-galloyl)-4-O-(galloyl)quinic acid (6). Their chemical structures were elucidated by NMR means. (AU)

• Processo FAPESP: 09/10975-3 - Isolamento de marcadores e desenvolvimento de forma farmacêutica sólida a partir do extrato hidroalcoólico das partes aéreas de Copaifera langsdorffii
• Beneficiário: Mauro Nogueira da Silva
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 11/13630-7 - Validação química e farmacológica de extratos e princípios ativos de espécies de Copaifera
• Beneficiário: Jairo Kenupp Bastos
• Modalidade de apoio: Auxílio à Pesquisa - Temático