Yacon (Smallanthus sonchifolius) and Lactobacillus acidophilus CRL 1014 reduce the early phases of colon carcinogenesis in male Wistar rats

Autor(es)

da Silva Almeida, Ana Paula ^[1] ; Avi, Camilla Martins ^[1] ; Barbisan, Luis Fernando ^[2] ; de Moura, Nelci Antunes ^[2] ; Ramos Caetano, Brunno Felipe ^[2] ; Romualdo, Guilherme Ribeiro ^[2] ; Sivieri, Katia ^[1]

Afiliação do(s) autor(es)

^[1] UNESP UnivEstadual Paulista Araraquara, Fac Pharmaceut Sci, Dept Food & Nutr, Sao Paulo, SP - Brazil

^[2] UNESP Sao Paulo State Univ, Inst Biosci, Dept Morphol, Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Food Research International; v. 74, p. 48-54, AUG 2015.
• Citações Web of Science: 4

Resumo

The modifying effects of aqueous yacon extract (AYE) and Lactobacillus acidophilus CRL 1014 against colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) in male Wistar rats were investigated. Animals were allocated into five groups: Cl: untreated group; G2: DMH-treated group; G3: DMH + L. acidophilus-treated group; G4: DMH + AYE-treated group; G5: DMH + L. acidophilus and AYE-treated group. A significant reduction (p < 0.05) in leukocyte DNA damage and in colonic cell proliferation was observed after the first DMH administration in G3 (probiotic), G4 (prebiotic) and G5 (synbiotic) groups. In this moment, a significant increase (p < 0.05) in colonic apoptosis was also observed in G3 (probiotic) and G5 (synbiotic) groups. In special, at five months after DMH administrations, a significant reduction (p < 0.05) in ACF development was observed in G3 (probiotic), G4 (prebiotic) and G5 (synbiotic) groups. Incidence of colon tumors was lower at five months in G4 (prebiotic) and G5 (synbiotic) groups but not in eight months after DMH administrations. In conclusion, the findings suggest that the oral treatments have potential effects as a chemopreventive agent against colon carcinogenesis on an early stage of tumor development. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 09/53878-8 - Implantação de sistema de três estágios de cultura contínuo e estudo da ação de probióticos, prebióticos e simbióticos sobre o câncer de cólon
• Beneficiário: Katia Sivieri
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores