Induction and nosocomial dissemination of carbapenem and polymyxin-resistant Klebsiella pneumoniae

Autor(es)

Gaspar, Gilberto Gambero ^[1] ; Bellissimo-Rodrigues, Fernando ^[2] ; de Andrade, Leonardo Neves ^[3] ; Darini, Ana Lucia ^[3] ; Martinez, Roberto ^[4]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Hosp Clin, Serv Controle Infeccao Hosp, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Med Social, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Clin Med, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Revista da Sociedade Brasileira de Medicina Tropical; v. 48, n. 4, p. 483-487, JUL-AUG 2015.
• Citações Web of Science: 7

Resumo

INTRODUCTION:Polymyxins are antimicrobial agents capable of controlling carbapenemase-producing Klebsiella pneumoniae infection.METHODS: We report a cluster of four patients colonized or infected by polymyxin-resistant and Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae.RESULTS: Three patients were hospitalized in adjacent wards, and two were admitted to the intensive care unit. The index case maintained prolonged intestinal colonization by KPC-producing K. pneumoniae. Three patients received polymyxin B before the isolation of polymyxin-resistant K. pneumoniae.CONCLUSIONS: Colonization by KPC-producing K. pneumoniae and previous use of polymyxin B may be causally related to the development of polymyxin-resistant microorganisms. (AU)

• Processo FAPESP: 11/08892-2 - Investigação molecular de linhagens de Klebsiella pneumoniae e plasmídeos carreando genes codificadores de beta-lactamases
• Beneficiário: Leonardo Neves de Andrade
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado