Induction and nosocomial dissemination of carbapenem and polymyxin-resistant Klebsiella pneumoniae

Author(s)

Gaspar, Gilberto Gambero ^[1] ; Bellissimo-Rodrigues, Fernando ^[2] ; de Andrade, Leonardo Neves ^[3] ; Darini, Ana Lucia ^[3] ; Martinez, Roberto ^[4]

Affiliation

^[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Hosp Clin, Serv Controle Infeccao Hosp, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Med Social, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Clin Med, Sao Paulo - Brazil

• Document type: Journal article
• Source: Revista da Sociedade Brasileira de Medicina Tropical; v. 48, n. 4, p. 483-487, JUL-AUG 2015.
• Web of Science Citations: 7

Abstract

INTRODUCTION:Polymyxins are antimicrobial agents capable of controlling carbapenemase-producing Klebsiella pneumoniae infection.METHODS: We report a cluster of four patients colonized or infected by polymyxin-resistant and Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae.RESULTS: Three patients were hospitalized in adjacent wards, and two were admitted to the intensive care unit. The index case maintained prolonged intestinal colonization by KPC-producing K. pneumoniae. Three patients received polymyxin B before the isolation of polymyxin-resistant K. pneumoniae.CONCLUSIONS: Colonization by KPC-producing K. pneumoniae and previous use of polymyxin B may be causally related to the development of polymyxin-resistant microorganisms. (AU)

• FAPESP's process: 11/08892-2 - Molecular investigation of Klebsiella pneumoniae strains and plasmids carrying beta-lactamases encoding genes
• Grantee: Leonardo Neves de Andrade
• Support Opportunities: Scholarships in Brazil - Post-Doctoral