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Molecular epidemiology of carbapenem-resistant enterobacteria and the study of intestinal colonization as a risk for infection or transmis-sion of carbapenemase-producing enterobacteria

Grant number: 18/19243-4
Support Opportunities:Regular Research Grants
Duration: April 01, 2019 - September 30, 2021
Field of knowledge:Biological Sciences - Genetics - Molecular Genetics and Genetics of Microorganisms
Principal Investigator:Patricia Severino
Grantee:Patricia Severino
Host Institution: Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE). Sociedade Beneficente Israelita Brasileira Albert Einstein (SBIBAE). São Paulo , SP, Brazil
Associated researchers: Fernando Gatti de Menezes ; Marinês Dalla Valle Martino


Antimicrobial resistance is an important public health issue. Multidrug resistant bacteria (MDR) are difficult to eradicate and their rapid dissemination lead to outbreaks and deaths in hospital environments. In Brazil, carbapenem-resistant Enterobacteriaceae (CRE), and specially those producing Klebsiela pneumoniae carbapenemase (KPC), are considered epidemic and mortality rates reach 48%. This scenario tends to worsen due to the lack of novel antibiotics. Studies that tackle the dissemination MDR bacteria are necessary. In this work we propose to identify endemic and sporadic bacterial clones in two hospitals located in Sao Paulo city that possess very different antibiotic and epidemiological surveillance programs. Genome sequencing will be used for the molecular characterization of CRE and to evaluate mechanisms of dissemination of resistance markers. We will also quantify the carriage load of CRE and KPC CRE using rectal swabs and associate results with infection and dissemination risk. Ultimately we aim to contribute with new strategies for the prevention and control of KPC CRE infections. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MIGLIORINI, LETICIA B.; DE SALES, ROMARIO O.; KOGA, PAULA C. M.; DOI, ANDRE M.; POEHLEIN, ANJA; TONIOLO, ALEXANDRA R.; MENEZES, FERNANDO G.; MARTINO, V, MARINES D.; GALES, ANA C.; BRUEGGEMANN, HOLGER; et al. Prevalence of bla(KPC-2), bla(KPC-3) and bla(KPC-30)-Carrying Plasmids in Klebsiella pneumoniae Isolated in a Brazilian Hospital. PATHOGENS, v. 10, n. 3, . (18/19243-4)
MIGLIORINI, LETICIA BUSATO; LEADEN, LAURA; DE SALES, ROMARIO OLIVEIRA; CORREA, NATHALIA PELLEGRINI; MARINS, MARYANA MARA; KOGA, PAULA CELIA MARIKO; TONIOLO, ALEXANDRA DO ROSARIO; DE MENEZES, FERNANDO GATTI; MARTINO, MARINES DALLA VALLE; MINGORANCE, JESUS; et al. The Gastrointestinal Load of Carbapenem-Resistant Enterobacteriacea Is Associated With the Transition From Colonization to Infection by Klebsiella pneumoniae Isolates Harboring the bla(KPC) Gene. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 12, p. 8-pg., . (18/19243-4)

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