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Resistence genes and plasmid typing of Enterobacteriaceae producing Extended spectrum betalactamase from Brazilian poultry and human strains

Grant number: 15/10140-0
Support Opportunities:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): August 07, 2015
Effective date (End): November 06, 2015
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Preventive Veterinary Medicine
Principal Investigator:Fernando Antonio de Avila
Grantee:Marita Vedovelli Cardozo
Supervisor: Michael Brouwer
Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
Research place: Wageningen University, Netherlands  
Associated to the scholarship:13/18280-0 - Molecular characterization and dissemination of Enterobacteriaceae producing Extended spectrum beta-lactamase from poultry production to its consumption, BP.PD


There are an increasing number of infections caused by Gram-negative bacteria producing extended spectrum betalactamases, and the emergence of new therapeutic resources does not follow the evolution of resistance mechanisms, making them a serious public health problem. The extended spectrum ²-lactamases (ESBL) are enzymes that hydrolyze the ²-lactam ring of penicillins, cephalosporins and aztreonam, conferring resistance to these antimicrobials. Brazil is the largest exporter of chicken means that the presence of ESBL and it becomes also a potential risk in the agribusiness sector. Based on this, the present project aims to identifying some groups of resistance genes and the plasmids encoding these genes of ESBL production in Enterobacteriaceae isolated from Brazilians chicken meat, chicken feaces and human feaces. The molecular detections will be by PCR and sequencing. Furthermore, the epidemiology profile of each sample will be featured by the sequencing of genes "housekeeping" (MLST) to clonal characterization of them. The results of this study will be essential to understanding the ESBL resistance genes profiles most commonly found in the chain of the broilers production in the state of São Paulo, and also to show the correlation between the presence of resistance genes in animals and humans.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CARDOZO, MARITA VEDOVELLI; LIAKOPOULOS, APOSTOLOS; BROUWER, MICHAEL; KANT, ARIE; LUDUVERIO PIZAURO, LUCAS JOSE; BORZI, MARIANA MONEZI; MEVIUS, DIK; DE AVILA, FERNANDO ANTONIO. Occurrence and Molecular Characteristics of Extended-Spectrum Beta-Lactamase-Producing Enterobacterales Recovered From Chicken, Chicken Meat, and Human Infections in Sao Paulo State, Brazil. FRONTIERS IN MICROBIOLOGY, v. 12, . (15/10140-0, 13/18280-0)

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