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Molecular characterization and dissemination of Enterobacteriaceae producing Extended spectrum beta-lactamase from poultry production to its consumption

Grant number: 13/18280-0
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): September 01, 2014
Effective date (End): April 30, 2017
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Preventive Veterinary Medicine
Principal Investigator:Fernando Antonio de Avila
Grantee:Marita Vedovelli Cardozo
Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
Associated scholarship(s):15/10140-0 - Resistence genes and plasmid typing of Enterobacteriaceae producing Extended spectrum betalactamase from Brazilian poultry and human strains, BE.EP.PD


The extended spectrum ²-lactamases (ESBL) are enzymes that hydrolyze the ²-lactam ring of penicillins, cephalosporins of the third and fourth generations and aztreonam, conferring resistance to these antimicrobials. There are an increasing number of infections caused by Gram-negative bacteria producing extended spectrum ²-lactamases, and the emergence of new therapeutic resources does not follow the evolution of resistance mechanisms, making them a serious public health problem. The fact that Brazil is the largest exporter of chicken means that the presence of ESBL become also a potential risk in the agribusiness sector. Based on this, the present study aims to analyze and characterize phenotypically and genotypically the ESBL production in Enterobacteriaceae isolated in the entire production chain of the poultry industry, including animals, food and consumers. After the phenotypic detection with the use of antimicrobials, to detect genotype will be by PCR and sequencing. Furthermore, the profile of each sample will be featured by pulsed field gel electrophoresis (PFGE) and also the sequencing of genes "housekeeping" (MLST) to clonal characterization of them. The results of this study will be essential to understanding the ESBL resistance genes profiles most commonly found in the chain of the broilers production in the state of São Paulo, and also to show the correlation between the presence of resistance genes in animals and humans.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CARDOZO, MARITA VEDOVELLI; LIAKOPOULOS, APOSTOLOS; BROUWER, MICHAEL; KANT, ARIE; LUDUVERIO PIZAURO, LUCAS JOSE; BORZI, MARIANA MONEZI; MEVIUS, DIK; DE AVILA, FERNANDO ANTONIO. Occurrence and Molecular Characteristics of Extended-Spectrum Beta-Lactamase-Producing Enterobacterales Recovered From Chicken, Chicken Meat, and Human Infections in Sao Paulo State, Brazil. FRONTIERS IN MICROBIOLOGY, v. 12, . (15/10140-0, 13/18280-0)

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