Deep brain stimulation induces antiapoptotic and anti-inflammatory effects in epileptic rats

Autor(es)

Amorim, Beatriz O. ^[1] ; Covolan, Luciene ^[1] ; Ferreira, Elenn ^[1] ; Brito, Jose Geraldo ^[1] ; Nunes, Diego P. ^[1] ; de Morais, David G. ^[1] ; Nobrega, Jose N. ^[2] ; Rodrigues, Antonio M. ^[3] ; deAlmeida, Antonio Carlos G. ^[3] ; Hamani, Clement ^{[2, 4]}

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Disciplina Neurofisiol, BR-04023062 Sao Paulo - Brazil

^[2] Ctr Addict & Mental Hlth, Behav Neurobiol Lab, Toronto, ON - Canada

^[3] Univ Fed Sao Joao del Rei, Dept Engn Biossistemas, BR-36301160 Sao Joao Del Rei, MG - Brazil

^[4] Univ Toronto, Toronto Western Hosp, Div Neurosurg, Toronto, ON M5T 2S8 - Canada

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF NEUROINFLAMMATION; v. 12, SEP 4 2015.
• Citações Web of Science: 12

Resumo

Background: Status epilepticus (SE) is a severe condition that may lead to hippocampal cell loss and epileptogenesis. Some of the mechanisms associated with SE-induced cell death are excitotoxicity, neuroinflammation, and apoptosis. Objective: The objective of the present study is to test the hypothesis that DBS has anti-inflammatory and antiapoptotic effects when applied during SE. Methods: Rats undergoing pilocarpine-induced SE were treated with anterior thalamic nucleus (AN) deep brain stimulation (DBS). Inflammatory changes and caspase 3 activity were measured within 1 week of treatment. Results: In pilocarpine-treated rats, DBS countered the significant increase in hippocampal caspase 3 activity and interleukin-6 (IL-6) levels that follows SE but had no effect on tumor necrosis factor alpha (TNF alpha). Conclusions: DBS has anti-inflammatory and antiapoptotic effects when given to animals undergoing status. (AU)

• Processo FAPESP: 12/50950-2 - Avaliação celular dos efeitos estimulação cerebral profunda no núcleo anterior do tálamo em modelos experimentais de epilepsia do lobo temporal
• Beneficiário: Luciene Covolan
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/10764-5 - Avaliação celular dos efeitos estimulação cerebral profunda no núcleo anterior do tálamo em modelos experimentais de epilepsia do lobo temporal
• Beneficiário: Beatriz Oliveira Amorim
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 11/50680-2 - Investigação multimodal da epileptogênese com ênfase na incorporação de novos modelos e novas ferramentas
• Beneficiário: Iscia Teresinha Lopes Cendes
• Modalidade de apoio: Auxílio à Pesquisa - Temático