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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Deep brain stimulation induces antiapoptotic and anti-inflammatory effects in epileptic rats

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Amorim, Beatriz O. [1] ; Covolan, Luciene [1] ; Ferreira, Elenn [1] ; Brito, Jose Geraldo [1] ; Nunes, Diego P. [1] ; de Morais, David G. [1] ; Nobrega, Jose N. [2] ; Rodrigues, Antonio M. [3] ; deAlmeida, Antonio Carlos G. [3] ; Hamani, Clement [2, 4]
Total Authors: 10
[1] Univ Fed Sao Paulo, Disciplina Neurofisiol, BR-04023062 Sao Paulo - Brazil
[2] Ctr Addict & Mental Hlth, Behav Neurobiol Lab, Toronto, ON - Canada
[3] Univ Fed Sao Joao del Rei, Dept Engn Biossistemas, BR-36301160 Sao Joao Del Rei, MG - Brazil
[4] Univ Toronto, Toronto Western Hosp, Div Neurosurg, Toronto, ON M5T 2S8 - Canada
Total Affiliations: 4
Document type: Journal article
Web of Science Citations: 12

Background: Status epilepticus (SE) is a severe condition that may lead to hippocampal cell loss and epileptogenesis. Some of the mechanisms associated with SE-induced cell death are excitotoxicity, neuroinflammation, and apoptosis. Objective: The objective of the present study is to test the hypothesis that DBS has anti-inflammatory and antiapoptotic effects when applied during SE. Methods: Rats undergoing pilocarpine-induced SE were treated with anterior thalamic nucleus (AN) deep brain stimulation (DBS). Inflammatory changes and caspase 3 activity were measured within 1 week of treatment. Results: In pilocarpine-treated rats, DBS countered the significant increase in hippocampal caspase 3 activity and interleukin-6 (IL-6) levels that follows SE but had no effect on tumor necrosis factor alpha (TNF alpha). Conclusions: DBS has anti-inflammatory and antiapoptotic effects when given to animals undergoing status. (AU)

FAPESP's process: 12/50950-2 - Cellular effects of deep brain stimulation in anterior thalamus nucleus in experimental models of temporal lobe epilepsy
Grantee:Luciene Covolan
Support type: Regular Research Grants
FAPESP's process: 12/10764-5 - Evaluation of cellular effects of deep brain stimulation of the anterior nucleus of the thalamus in experimental models of temporal lobe epilepsy
Grantee:Beatriz Oliveira Amorim
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 11/50680-2 - Multimodal investigation of epileptogenesis with emphasis in the implementation of new animal models and new tools
Grantee:Iscia Teresinha Lopes Cendes
Support type: Research Projects - Thematic Grants