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Cellular effects of deep brain stimulation in anterior thalamus nucleus in experimental models of temporal lobe epilepsy

Grant number: 12/50950-2
Support Opportunities:Regular Research Grants
Duration: October 01, 2012 - September 30, 2014
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Luciene Covolan
Grantee:Luciene Covolan
Host Institution: Pró-Reitoria de Pós-Graduação e Pesquisa. Universidade Federal de São Paulo (UNIFESP). São Paulo , SP, Brazil


Temporal lobe epilepsy (TLE) is among the most frequent disturb of central nervous system. In clinical practice, deep brain stimulation (DBS) has been the alternative choice for treatment of those patients non responsive to conventional antiepileptic drugs and also, are not good candidates for surgical resection of epileptic foci. As the anterior thalamus nucleus (NA) has a central localization in the limbic circuitry, has been the most frequently target for DBS to control seizures. In previous studies, our group have demonstrated that the 500μA current intensity is able to reduce the latency to status epilepticus (SE) onset after pilocarpine systemic injection. In spite of good results obtained in clinical trials and in experimental models of epilepsy, it action mechanisms remain unknown. In this study our aim is to investigate hippocampal cellular alteration caused by NA DBS in different phases of the pilocarpine model of TLE. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERREIRA, ELENN SOARES; VIEIRA, LAIS GABRIELLE; MORAES, DANIELA MACEDO; AMORIM, BEATRIZ O.; MALHEIROS, JACKELINE MORAES; HAMANI, CLEMENT; COVOLAN, LUCIENE. Long-Term Effects of Anterior Thalamic Nucleus Deep Brain Stimulation on Spatial Learning in the Pilocarpine Model of Temporal Lobe Epilepsy. NEUROMODULATION, v. 21, n. 2, p. 160-167, . (12/50950-2)
COVOLAN, LUCIENE; DE ALMEIDA, ANTONIO-CARLOS G.; AMORIM, BEATRIZ; CAVARSAN, CLARISSA; MIRANDA, MAISA FERREIRA; AARAO, MAYRA C.; MADUREIRA, ANA PAULA; RODRIGUES, ANTONIO M.; NOBREGA, JOSE N.; MELLO, LUIZ E.; et al. Effects of Anterior Thalamic Nucleus Deep Brain Stimulation in Chronic Epileptic Rats. PLoS One, v. 9, n. 6, . (12/50950-2, 11/50680-2)
AMORIM, BEATRIZ O.; COVOLAN, LUCIENE; FERREIRA, ELENN; BRITO, JOSE GERALDO; NUNES, DIEGO P.; DE MORAIS, DAVID G.; NOBREGA, JOSE N.; RODRIGUES, ANTONIO M.; DEALMEIDA, ANTONIO CARLOS G.; HAMANI, CLEMENT. Deep brain stimulation induces antiapoptotic and anti-inflammatory effects in epileptic rats. JOURNAL OF NEUROINFLAMMATION, v. 12, . (12/50950-2, 12/10764-5, 11/50680-2)
AMORIM, BEATRIZ OLIVEIRA; HAMANI, CLEMENT; FERREIRA, ELENN; MIRANDA, MAISA FERREIRA; FERNANDES, MARIA JOSE S.; RODRIGUES, ANTONIO M.; DE ALMEIDA, ANTONIO-CARLOS G.; COVOLAN, LUCIENE. Effects of A1 receptor agonist/antagonist on spontaneous seizures in pilocarpine-induced epileptic rats. Epilepsy & Behavior, v. 61, p. 168-173, . (12/50950-2, 12/10764-5, 11/50680-2)

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