Caryocar brasiliense camb protects against genomic and oxidative damage in urethane-induced lung carcinogenesis

Autor(es)

Colombo, N. B. R. ^[1] ; Rangel, M. P. ^[1] ; Martins, V. ^[1] ; Hage, M. ^[2] ; Gelain, D. P. ^[3] ; Barbeiro, D. F. ^[4] ; Grisolia, C. K. ^[5] ; Parra, E. R. ^[1] ; Capelozzi, V. L. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Dept Patol, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Fac Med, Lab Poluicao Atmosfer, Sao Paulo, SP - Brazil

^[3] Univ Rio Grande Sul, Dept Stress Oxidat, Porto Alegre, RS - Brazil

^[4] Univ Sao Paulo, Dept Emergencia Clin, Sao Paulo, SP - Brazil

^[5] Univ Brasilia, Dept Genet & Morfol, Brasilia, DF - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Medical and Biological Research; v. 48, n. 9, p. 852-862, SEP 2015.
• Citações Web of Science: 11

Resumo

The antioxidant effects of Caryocar brasiliense Camb, commonly known as the pequi fruit, have not been evaluated to determine their protective effects against oxidative damage in lung carcinogenesis. In the present study, we evaluated the role of pequi fruit against urethane-induced DNA damage and oxidative stress in forty 8-12 week old male BALB/C mice. An in vivo comet assay was performed to assess DNA damage in lung tissues and changes in lipid peroxidation and redox cycle antioxidants were monitored for oxidative stress. Prior supplementation with pequi oil or its extract (15 µL, 60 days) significantly reduced urethane-induced oxidative stress. A protective effect against DNA damage was associated with the modulation of lipid peroxidation and low protein and gene expression of nitric oxide synthase. These findings suggest that the intake of pequi fruit might protect against in vivo genotoxicity and oxidative stress. (AU)

• Processo FAPESP: 11/02118-3 - Ação dos compostos antioxidantes na redução do estresse oxidativo em modelo experimental de câncer de pulmão: estudo do pequi (Caryocar brasiliense Camb.)
• Beneficiário: Natália Beatriz Rigoldi Colombo
• Modalidade de apoio: Bolsas no Brasil - Mestrado