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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Effects of Photodynamic Process (PDP) in Implant Osseointegration: A Histologic and Histometric Study in Dogs

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Autor(es):
Pinto Faria, Paulo Esteves [1] ; Borges Felipucci, Daniela Nair [2] ; Simioni, Andreza Ribeiro [3] ; Primo, Fernando Lucas [4] ; Tedesco, Antonio Claudio [4] ; Salata, Luiz Antonio [5]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Ribeirao Preto, Sch Dent, Oral & Maxillofacial Surg, Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Dent Ribeirao Preto, Dept Dent Mat & Prosthodont, BR-14040904 Ribeirao Preto, SP - Brazil
[3] Univ Paraiba Valley, Inst Res & Dev, Organ Synth Lab, Sao Jose Dos Campos - Brazil
[4] Univ Sao Paulo, Fac Philosophy & Sci Ribeirao Preto, Dept Chem, BR-14040904 Ribeirao Preto, SP - Brazil
[5] Univ Sao Paulo, Fac Dent, Dept Oral & Maxillofacial Surg & Periodont, BR-14040904 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH; v. 17, n. 5, p. 879-890, OCT 2015.
Citações Web of Science: 2
Resumo

BackgroundThe combination between photosensitivity substances with laser or light-emitting diode (LED) form the photodynamic therapy basis that consists of photosensitivity drug activated by low-frequency light. This mechanism is used in soft tissue healing process to improve the oxygen tension leading to a fast revascularization. PurposeThe objective of this study was to evaluate the effects of photosensitivity drugs activated through LED on osseointegration process. Materials and MethodsEight mongrel dogs underwent implant therapy in four mandibular bone defects using 5.0mm trephine drill on each side of the mandible. The defects were randomly filled up with (1) Nano emulsion, (2) liposome, (3) blood clot, and (4) autogenous bone. LED with visible and infrared light were applied after 48/72 postoperative hours on four dogs and after 96/120 postoperative hours in the other four dogs. All the animals were euthanized at 15 days after surgery. Ground sections slides were prepared from the experimental site for histomorphometry and histological analysis. ResultsNo difference was detected in the following parameters: bone-implant contact, bone inside the defect and crest level on LED 48/72. Significant difference was detected inside the defect when filled with autogenous bone (p=.0238) on LED 96/120. When LED 48/72 and LED 96/120 were compared, significant higher bone formation was detected when autogenous bone on bone-implant contact (p=.0043) and bone inside the defect (p=.0008) was used. ConclusionThe use of photosensitivity drugs activated by LED demonstrated a tendency to stimulate bone formation, similar to autogenous bone graft on later time point. (AU)

Processo FAPESP: 07/08442-1 - Avaliação histológica, histomorfométrica e imunoistoquímica do efeito de fármacos fostossensíveis ativados por laser no reparo ósseo e osseointegração de implantes de titânio: estudo em coelhos e cães
Beneficiário:Luiz Antonio Salata
Linha de fomento: Auxílio à Pesquisa - Regular