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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of Photodynamic Process (PDP) in Implant Osseointegration: A Histologic and Histometric Study in Dogs

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Author(s):
Pinto Faria, Paulo Esteves [1] ; Borges Felipucci, Daniela Nair [2] ; Simioni, Andreza Ribeiro [3] ; Primo, Fernando Lucas [4] ; Tedesco, Antonio Claudio [4] ; Salata, Luiz Antonio [5]
Total Authors: 6
Affiliation:
[1] Univ Ribeirao Preto, Sch Dent, Oral & Maxillofacial Surg, Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Dent Ribeirao Preto, Dept Dent Mat & Prosthodont, BR-14040904 Ribeirao Preto, SP - Brazil
[3] Univ Paraiba Valley, Inst Res & Dev, Organ Synth Lab, Sao Jose Dos Campos - Brazil
[4] Univ Sao Paulo, Fac Philosophy & Sci Ribeirao Preto, Dept Chem, BR-14040904 Ribeirao Preto, SP - Brazil
[5] Univ Sao Paulo, Fac Dent, Dept Oral & Maxillofacial Surg & Periodont, BR-14040904 Ribeirao Preto, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH; v. 17, n. 5, p. 879-890, OCT 2015.
Web of Science Citations: 1
Abstract

BackgroundThe combination between photosensitivity substances with laser or light-emitting diode (LED) form the photodynamic therapy basis that consists of photosensitivity drug activated by low-frequency light. This mechanism is used in soft tissue healing process to improve the oxygen tension leading to a fast revascularization. PurposeThe objective of this study was to evaluate the effects of photosensitivity drugs activated through LED on osseointegration process. Materials and MethodsEight mongrel dogs underwent implant therapy in four mandibular bone defects using 5.0mm trephine drill on each side of the mandible. The defects were randomly filled up with (1) Nano emulsion, (2) liposome, (3) blood clot, and (4) autogenous bone. LED with visible and infrared light were applied after 48/72 postoperative hours on four dogs and after 96/120 postoperative hours in the other four dogs. All the animals were euthanized at 15 days after surgery. Ground sections slides were prepared from the experimental site for histomorphometry and histological analysis. ResultsNo difference was detected in the following parameters: bone-implant contact, bone inside the defect and crest level on LED 48/72. Significant difference was detected inside the defect when filled with autogenous bone (p=.0238) on LED 96/120. When LED 48/72 and LED 96/120 were compared, significant higher bone formation was detected when autogenous bone on bone-implant contact (p=.0043) and bone inside the defect (p=.0008) was used. ConclusionThe use of photosensitivity drugs activated by LED demonstrated a tendency to stimulate bone formation, similar to autogenous bone graft on later time point. (AU)

FAPESP's process: 07/08442-1 - Histological, histomorphometrical and imunohistochemical evaluation of the effects of photosensitive laser-activated pharmacos on bone repair and osseointegration of titanium implants: a study in rabbits and dogs
Grantee:Luiz Antonio Salata
Support Opportunities: Regular Research Grants