Direct synthesis of magnetite nanoparticles from iron(II) carboxymethylcellulose and their performance as NMR contrast agents

Autor(es)

da Silva, Delmarcio Gomes ^[1] ; Toma, Sergio Hiroshi ^[1] ; de Melo, Fernando Menegatti ^[1] ; Carvalho, Larissa Vieira C. ^[2] ; Magalhaes, Alvicler ^[2] ; Sabadini, Edvaldo ^[2] ; dos Santos, Antonio Domingues ^[3] ; Araki, Koiti ^[1] ; Toma, Henrique E. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim, Sao Carlos, SP - Brazil

^[2] Univ Estadual Campinas UNICAMP, Inst Quim, Campinas, SP - Brazil

^[3] Univ Sao Paulo, Inst Fis, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Magnetism and Magnetic Materials; v. 397, p. 28-32, JAN 1 2016.
• Citações Web of Science: 11

Resumo

Iron(II) carboxymethylcellulose (CMC) has been successfully employed in the synthesis of hydrophylic magnetite nanoparticles stabilized with a biopolymer coating, aiming applications in NMR imaging. The new method encompasses a convenient one-step synthetic procedure, allowing a good size control and yielding particles of about 10 nm (core size). In addition to the biocompatibility, the nanoparticles have promoted a drastic reduction in the transverse relaxation time (T-2) of the water protons. The relaxivity rates have been investigated as a function of the nanoparticles concentration, showing a better performance in relation to the common NMR contrast agents available in the market. (C) 2015 Elsevier B.V. All rights reserved (AU)

• Processo FAPESP: 13/24725-4 - Química supramolecular e nanotecnologia
• Beneficiário: Henrique Eisi Toma
• Modalidade de apoio: Auxílio à Pesquisa - Temático