Direct synthesis of magnetite nanoparticles from iron(II) carboxymethylcellulose and their performance as NMR contrast agents

Author(s)

da Silva, Delmarcio Gomes ^[1] ; Toma, Sergio Hiroshi ^[1] ; de Melo, Fernando Menegatti ^[1] ; Carvalho, Larissa Vieira C. ^[2] ; Magalhaes, Alvicler ^[2] ; Sabadini, Edvaldo ^[2] ; dos Santos, Antonio Domingues ^[3] ; Araki, Koiti ^[1] ; Toma, Henrique E. ^[1]

Affiliation

^[1] Univ Sao Paulo, Inst Quim, Sao Carlos, SP - Brazil

^[2] Univ Estadual Campinas UNICAMP, Inst Quim, Campinas, SP - Brazil

^[3] Univ Sao Paulo, Inst Fis, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: Journal of Magnetism and Magnetic Materials; v. 397, p. 28-32, JAN 1 2016.
• Web of Science Citations: 11

Abstract

Iron(II) carboxymethylcellulose (CMC) has been successfully employed in the synthesis of hydrophylic magnetite nanoparticles stabilized with a biopolymer coating, aiming applications in NMR imaging. The new method encompasses a convenient one-step synthetic procedure, allowing a good size control and yielding particles of about 10 nm (core size). In addition to the biocompatibility, the nanoparticles have promoted a drastic reduction in the transverse relaxation time (T-2) of the water protons. The relaxivity rates have been investigated as a function of the nanoparticles concentration, showing a better performance in relation to the common NMR contrast agents available in the market. (C) 2015 Elsevier B.V. All rights reserved (AU)

• FAPESP's process: 13/24725-4 - Supramolecular chemistry and nanotechnology
• Grantee: Henrique Eisi Toma
• Support Opportunities: Research Projects - Thematic Grants