Relationship between Brain Age-Related Reduction in Gray Matter and Educational Attainment

Autor(es):Mostrar menos -

Rzezak, Patricia ^{[1, 2]} ; Squarzoni, Paula ^{[1, 2]} ; Duran, Fabio L. ^{[1, 2]} ; Ferraz Alves, Tania de Toledo ^{[1, 2]} ; Tamashiro-Duran, Jaqueline ^{[1, 2]} ; Bottino, Cassio M. ^[3] ; Ribeiz, Salma ^[3] ; Lotufo, Paulo A. ^{[4, 5]} ; Menezes, Paulo R. ^[6] ; Scazufca, Marcia ^[7] ; Busatto, Geraldo F. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Lab Psychiat Neuroimaging, Dept & Inst Psychiat, Fac Med, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci, Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Old Age Res Grp PROTER, Dept & Inst Psychiat, Fac Med, Sao Paulo, SP - Brazil

^[4] Univ Sao Paulo, Fac Med, Sao Paulo, SP - Brazil

^[5] Univ Sao Paulo, Ctr Clin & Epidemiol Res, Univ Hosp, Sao Paulo, SP - Brazil

^[6] Univ Sao Paulo, Dept Prevent Med, Fac Med, Sao Paulo, SP - Brazil

^[7] Univ Sao Paulo, Lab Psychopharmacol & Clin Psychophysiol LIM 23, Fac Med, Inst Psychiat, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 10, n. 10 OCT 16 2015.
• Citações Web of Science: 11

Resumo

Inter-subject variability in age-related brain changes may relate to educational attainment, as suggested by cognitive reserve theories. This voxel-based morphometry study investigated the impact of very low educational level on the relationship between regional gray matter (rGM) volumes and age in healthy elders. Magnetic resonance imaging data were acquired in elders with low educational attainment (less than 4 years) (n = 122) and high educational level (n = 66), pulling together individuals examined using either of three MRI scanners/acquisition protocols. Voxelwise group comparisons showed no rGM differences (p<0.05, family-wise error corrected for multiple comparisons). When within-group voxel-wise patterns of linear correlation were compared between high and low education groups, there was one cluster of greater rGM loss with aging in low versus high education elders in the left anterior cingulate cortex (p<0.05, FWE-corrected), as well as a trend in the left dorsomedial prefrontal cortex (p<0.10). These results provide preliminary indication that education might exert subtle protective effects against age-related brain changes in healthy subjects. The anterior cingulate cortex, critical to inhibitory control processes, may be particularly sensitive to such effects, possibly given its involvement in cognitive stimulating activities at school or later throughout life. (AU)

• Processo FAPESP: 12/13065-0 - Uso de assinaturas neurobiológicas para a determinação de idosos sujeitos à doença de Alzheimer
• Beneficiário: Patricia Rzezak Tencer
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 12/50329-6 - Neurociência translacional da doença de Alzheimer: estudos pré-clínicos e clínicos do peptídeo b-amiloide e outros biomarcadores
• Beneficiário: Geraldo Busatto Filho
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 04/09586-9 - Deficits cognitivos e alteracoes estruturais em exames de ressonancia magnetica: importancia para o desfecho da depressao em idosos.
• Beneficiário: Cássio Machado de Campos Bottino
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/03231-3 - Padrões de atrofia cortical e déficits cognitivos associados ao envelhecimento saudável: um estudo de seguimento por ressonância magnética estrutural
• Beneficiário: Paula Squarzoni da Silveira
• Modalidade de apoio: Bolsas no Brasil - Doutorado