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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Association of oxidative stress biomarkers with adiposity and clinical staging in women with breast cancer

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Autor(es):
Carioca, A. A. F. [1] ; Verde, S. M. M. L. [1, 2] ; Luzia, L. A. [1] ; Rondo, P. H. C. [1] ; Latorre, M. R. D. O. [3] ; Ellery, T. H. P. [1] ; Damasceno, N. R. T. [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, BR-01246904 Sao Paulo - Brazil
[2] Univ Fortaleza, Nutr Course, Fortaleza, Ceara - Brazil
[3] Univ Sao Paulo, Sch Publ Hlth, Dept Epidemiol, BR-01246904 Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: European Journal of Clinical Nutrition; v. 69, n. 11, p. 1256-1261, NOV 2015.
Citações Web of Science: 4
Resumo

BACKGROUND/OBJECTIVES: Breast cancer is a disease characterised by both oxidative reactions and inflammation. However, few studies have focused on the oxidative and inflammatory biomarkers. The aim of the present study was to evaluate the association between oxidative stress markers and adiposity and clinical staging, as well as the association between the oxidative and the antioxidant biomarkers of women with breast cancer. SUBJECTS/METHODS: A total of 135 cases of breast cancer occurring in 2011 and 2012 were assessed. After exclusions, 101 pre- and post-menopausal women with clinical staging I to IV were eligible to participate in the study. The anthropometric evaluation was performed by collecting data on waist circumference, body mass index and body composition. The socioeconomic and clinical profiles were determined using a standard questionnaire. For the oxidative biomarkers, thiobarbituric acid reactive substances (TBARS), oxidative DNA damage (8-hydroxy-2-deoxyguanosine (8-OHdG)), low-density lipoprotein(-) (LDL(-)), autoantibody anti-LDL(-) and liposoluble antioxidants (a-tocopherol, retinol and beta-carotene) were analysed. The data were analysed using differences in the mean values, correlation tests and multiple linear regression. RESULTS: The antioxidant levels were higher in postmenopausal women with clinical staging I and II and negative lymph nodes. The TBARS level was associated with clinical staging. Adiposity was associated with levels of retinol and 8-OHdG, whereas LDL(-), 8-OHdG and TBARS were correlated with liposoluble antioxidants after adjusting for the confounders. CONCLUSIONS: The adiposity and clinical staging of patients were associated with oxidative stress. The oxidative and antioxidant biomarkers showed a negative correlation in patients with breast cancer. (AU)

Processo FAPESP: 11/15590-2 - Influência do índice W-3 sobre a oxidabilidade da LDL, inflamação e a composição corporal em mulheres com câncer de mama
Beneficiário:Antonio Augusto Ferreira Carioca
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 10/19207-6 - Papel da adiposidade sobre a inflamação, oxidação e adipocitocinas na neoplasia mamária
Beneficiário:Nágila Raquel Teixeira Damasceno
Linha de fomento: Auxílio à Pesquisa - Regular