Aging and Parkinson's disease as functional models of temporal order perception

Autor(es)

da Silva, Carolina Feher ^[1] ; Silva Morgero, Kelly Cristina ^[2] ; Mota, Amanda Manzini ^[2] ; Pimentel Piemonte, Maria Elisa ^[3] ; Chrysostomo Baldo, Marcus Vinicius ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Gen Phys, Inst Phys, BR-05508090 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508000 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Med, Dept Phys Therapy Phonoaudiol & Occupat Therapy, BR-05508000 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Neuropsychologia; v. 78, p. 1-9, NOV 2015.
• Citações Web of Science: 4

Resumo

Objective: Our study evaluates how aging and Parkinson's disease (PD) alter temporal order judgment (TOJ). Method: Two TOJ experiments were performed with young participants, healthy elderly participants, and PD patients. Two white squares were presented on opposite sides of a screen and participants responded which appeared first. In Experiment 1, it was assessed how accurately each group could judge temporal order at intervals from 0 ms to 167 ms. Detectability, the capacity of detecting which stimulus appeared first, was measured. In Experiment 2, participants were asked to orient their attention to the hemifield indicated by a cue. The PSS ({''}point of subjective simultaneity{''}), where the participant was equally likely to respond that either stimulus appeared first, was measured. Results: In Experiment 1, PD patients had smaller detectability than healthy elderly (p < 0.05) and young participants (p < 0.001), and healthy elderly participants had smaller detectability than young participants (p < 0.001). In Experiment 2, PSS was 29 ms for young participants, 121 ms for healthy elderly participants, and 283 ms for PD patients; differences were statistically significant for comparisons between PD patients and healthy elderly participants (p < 0.001), PD patients and young participants (p < 0.001), and healthy elderly and young participants (p < 0.04). Conclusions: TOJ is impaired by aging and PD. Our results suggest that dopamine loss increases latency and variability in visual decision making due to a lower signal-to-noise ratio in the visual pathways. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 03/11139-8 - Dinâmica temporal da percepção visual e sua modulação sensorial, atencional e comportamental
• Beneficiário: Marcus Vinícius Chrysóstomo Baldo
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/10694-0 - Papel da recompensa e dos núcleos da base na tomada de decisão
• Beneficiário: Carolina Feher da Silva
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado