Resistance training minimizes catabolic effects induced by sleep deprivation in rats

Autor(es):Mostrar menos -

Monico-Neto, Marcos ^{[1, 2]} ; Moreira Antunes, Hanna Karen ^{[3, 2]} ; Lee, Kil Sun ^[4] ; Phillips, Stuart M. ^[5] ; de Campos Giampa, Sara Quaglia ^{[3, 2]} ; Souza, Helton de Sa ^{[1, 2]} ; Dattilo, Murilo ^{[1, 2]} ; Medeiros, Alessandra ^[3] ; de Moraes, Wilson Max ^[3] ; Tufik, Sergio ^[1] ; de Mello, Marco Tulio ^{[1, 6]}

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo - Brazil

^[2] Lab Interdisciplinar Fisiol & Exercicio, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Dept Biosci, Santos - Brazil

^[4] Univ Fed Sao Paulo, Dept Biochem, Sao Paulo - Brazil

^[5] McMaster Univ, Dept Kinesiol, Hamilton, ON - Canada

^[6] Univ Fed Minas Gerais, Sch Phys Educ Physiotherapy & Occupat Therapy, Belo Horizonte, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: APPLIED PHYSIOLOGY NUTRITION AND METABOLISM; v. 40, n. 11, p. 1143-1150, NOV 2015.
• Citações Web of Science: 11

Resumo

Sleep deprivation (SD) can induce muscle atrophy. We aimed to investigate the changes underpinning SD-induced muscle atrophy and the impact of this condition on rats that were previously submitted to resistance training (RT). Adult male Wistar EPM-1 rats were randomly allocated into 1 of 5 groups: control, sham, SD (for 96 h), RT, and RT+SD. The major outcomes of this study were muscle fiber cross-sectional area (CSA), anabolic and catabolic hormone profiles, and the abundance of select proteins involved in muscle protein synthesis and degradation pathways. SD resulted in muscle atrophy; however, when SD was combined with RT, the reduction in muscle fiber CSA was attenuated. The levels of IGF-1 and testosterone were reduced in SD animals, and the RT+SD group had higher levels of these hormones than the SD group. Corticosterone was increased in the SD group compared with the control group, and this increase was minimized in the RT+SD group. The increases in corticosterone concentrations paralleled changes in the abundance of ubiquitinated proteins and the autophagic proteins LC3 and p62/SQSTM1, suggesting that corticosterone may trigger these changes. SD induced weight loss, but this loss was minimized in the RT+SD group. We conclude that SD induced muscle atrophy, probably because of the increased corticosterone and catabolic signal. High-intensity RT performed before SD was beneficial in containing muscle loss induced by SD. It also minimized the catabolic signal and increased synthetic activity, thereby minimizing the body's weight loss. (AU)

• Processo FAPESP: 13/00152-5 - Efeito do exercício físico resistido no músculo esquelético e cardíaco de ratos Wistar submetidos a privação de sono paradoxal
• Beneficiário: Hanna Karen Moreira Antunes
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/15962-7 - Efeitos do exercício físico resistido nas vias tróficas e atróficas da musculatura esquelética de ratos submetidos à privação de sono paradoxal
• Beneficiário: Marcos Mônico Neto
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 98/14303-3 - Center for Sleep Studies
• Beneficiário: Sergio Tufik
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs