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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Changes in T-cell phenotype and cytokines profile in maternal blood, cord blood and colostrum of diabetic mothers

Texto completo
Autor(es):
Gomes Fagundes, Danny Laura [1] ; Franca, Eduardo Luzia [2] ; da Silva Fernandes, Rubian Trindade [2] ; Pernet Hara, Cristiane de Castro [2] ; Morceli, Glilciane [1] ; Honorio-Franca, Adenilda Cristina [2] ; Paranhos Calderon, Iracema de Mattos [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ UNESP, Botucatu Med Sch, Grad Program Gynecol Obstet & Mastol, Sao Paulo - Brazil
[2] Univ Fed Mato Grosso, Inst Biol & Hlth Sci, Barra Do Garcas, Mato Grosso - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Journal of Maternal-Fetal & Neonatal Medicine; v. 29, n. 6, p. 998-1004, MAR 18 2016.
Citações Web of Science: 8
Resumo

Objective: The present study evaluated the cells and cytokine of maternal blood, cord blood and colostrum of diabetic mothers.Methods: The women evaluated were divided according to their body mass index (BMI) and glycemic status into non-diabetic (ND - N=15), mild gestational hyperglycemic (MGH - N=15), diabetes mellitus gestational (DMG - N=13) and type-2 diabetes mellitus (DM2 - N=15) groups. The subsets of cells and cytokine profile were determined by flow cytometry.Results: Maternal blood from MGH group had increase percentage of CD3(+)T cells, and DM-2 group had decrease percentage of CD4(+) T cells. The cord blood from hyperglycemic groups showed lower percentage of CD3(+) T cells expressing CD45RO(+) and higher of CD4(+) T cells and CD4(+) T cells expressing CD45RA(+). In the colostrum, the CD4(+) T cells and CD4(+) T cells expressed CD45RA(+) increase in hyperglycemic groups. The DM2 group exhibited higher IL17 levels in maternal blood. IFN- was lower in cord blood from MGH and DMG groups with overweight/obese. Irrespective of the glycemic status, IL6 was higher in colostrum.Conclusion: The results obtained suggest that maternal hyperglycemia modifies the phenotypes of T cells and cytokines profile in maternal, cord blood and colostrum. (AU)

Processo FAPESP: 12/24212-4 - Marcadores da imunomodulação no sangue materno e fetal e nas placentas de mães diabéticas ou com hiperglicemia gestacional leve
Beneficiário:Cristiane de Castro Pernet Hara
Modalidade de apoio: Bolsas no Brasil - Doutorado
Processo FAPESP: 12/18033-0 - Marcadores da imunomodulação no sangue materno e fetal e nas placentas de mães diabéticas ou com hiperglicemia gestacional leve
Beneficiário:Glilciane Morceli
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado